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TranscriptomicsEts-domain transcription factor Ets21c and nuclear receptor Ftz-F1 are novel effectors of JNK promoting tumor malignancy
Cancer represents a complex family of diseases, characterized by the uncontrolled malignant growth of a particular cell type and by metastatic dissemination of these transformed cells to secondary sites. The hallmark tumor features emerge as a result of aberrant cellular signaling and pathological g...
ORGANISM(S): Drosophila melanogaster 
2015-11-04 | E-GEOD-65261 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
UnknownPolymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk.
Not available
S-EPMC2628929 | biostudies-literature
ProteomicsExtracellular matrix proteolysis maintains synaptic plasticity during brain development
Synapses are highly dynamic during early brain development, enabling the rapid adaptations that occur as neural circuits remodel in response to experience. The extracellular matrix (ECM) has been proposed as a critical regulator of synaptic plasticity in the brain. However, the molecular mechanisms ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD060477 | Pride
Synaptic plasticity Synapse Extracellular matrix Brain development 
UnknownPotential of a Novel Chemical Compound Targeting Matrix Metalloprotease-13 for Early Osteoarthritis: An In Vitro Study.
Not available
S-EPMC8910651 | biostudies-literature
ProteomicsProfiling the proteolytic dysfunction in digital dermatitis in cattle and the therapeutic use of a non-antimicrobial matrix metalloproteinase inhibitor
ABSTRACT Digital dermatitis (DD) is a painful inflammatory skin disease affecting the digital regions of cattle feet, linked to pathogenic Treponemes spp. This condition imposes a substantial economic burden on the cattle industry attributable to lameness and subsequent production inefficiencies. Cu...
ORGANISM(S): Bos taurus (Bovine) 
2025-09-19 | PXD060742 | Pride
: proteolytic dysfunction  metalloprotease inhibitor  oxytetracycline  digital dermatitis  cattle  treponema spp. 
Unknown(2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors.
Not available
S-EPMC3050611 | biostudies-literature
Transcriptomics4-week mouse comparative study on effect of neutralizing IL-17A, IL-17F and TNFa antibodies
Molecular profiling of effect of TNFα neutralization in contrast to anti-IL-17A or anti-IL-17F treatment for 28 days in lungs of M. tuberculosis infected C57BL/6 mice. Animals were treated once per week (starting day-1) with anti-mouse IL-17A or IL-17F antibodies (20 mg/kg i.p.), anti-mouse TNFα a...
ORGANISM(S): Mus musculus 
2016-12-02 | E-MTAB-5218 | biostudies-arrayexpress
UnknownA metalloprotease secreted by the insect pathogen Photorhabdus luminescens induces melanization.
Not available
S-EPMC2168055 | biostudies-literature
UnknownProtease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche.
Not available
S-EPMC8861167 | biostudies-literature
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