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MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11858 | MetaboLights
MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11844 | MetaboLights
ProteomicsO-Fucose glycans on mouse NOTCH1 from activated T cells of Fringe mutant mice
NOTCH1 (N1) is a transmembrane receptor that initiates a cell-cell signaling pathway controlling various cell fate specifications in metazoans. The addition of O-fucose by Protein O-fucosyltransferase 1 (POFUT1) to Epidermal Growth Factor-like (EGF) repeats in the N1 extracellular domain is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD031297 | Pride
T cell Notch1 O-fucose Fringe Pofut1 
TranscriptomicsThe Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanism behind this process remains unclear. Here we show that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, which is accompanied by the senescence-associated secretory phenotype...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-49968 | biostudies-arrayexpress
TranscriptomicsHuman induced pluripotent stem cells (iPSCs) derived from T-cell compared with that from adult dermal fibroblast (aHDF) [gene expression]
In this study we determine the transcriptional profile by microarray of iPSCs and iPSC-derived neurospheres generated from T-cells or aHDF by using direct neurosphere method. iPSCs and iPSC-derived tertiary neurospheres generated from T-cells or aHDF subjected to the gene expression microarray analy...
ORGANISM(S): Homo sapiens 
2016-01-14 | E-GEOD-76830 | biostudies-arrayexpress
UnknownLigand-Based CAR-T Cells Targeting EGFR Exhibit Favorable Antitumor Effects Against Gynecologic Malignancies.
Not available
S-EPMC12317388 | biostudies-literature
TranscriptomicsTranscription profiling of human CD4-positive cells purified from peripheral blood of ATL patients
CD4-positive cells purified from peripheral blood of ATL patients.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-1466 | biostudies-arrayexpress
UnknownFrequent STAT3 mutations in CD8+ T cells from patients with pure red cell aplasia.
Not available
S-EPMC6199660 | biostudies-literature
UnknownFunctional Analysis of Dendritic Cells Generated from T-iPSCs from CD4+ T Cell Clones of Sjogren's Syndrome.
Not available
S-EPMC5425788 | biostudies-literature
UnknownRobust CD8+ T-cell proliferation and diversification after mogamulizumab in patients with adult T-cell leukemia-lymphoma.
Not available
S-EPMC7252545 | biostudies-literature
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