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MetabolomicsPostprandial Metabolism is Impaired in Overweight Normoglycemic Young Adults without Family History of Diabetes

While the risk factors for Type 2 diabetes (T2DM) are known, early predictive markers of transition from normal to a prediabetes state are unidentified. We studied the basal metabolism and metabolic response to a mixed-meal challenge in 110 healthy subjects in the age group of 18 to 40 years (Mal...

2019-03-14 | MTBLS743 | MetaboLights
MetabolomicsEFO: In preparation - Early Metabolic Predictors of Type 2 Diabetes Mellitus in Normoglycemic Adults: Insights from Six-Year Prospective Cohort Study

INTRODUCTION: Type 2 Diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often preceded by latent metabolic disruptions. Early detection of metabolic alterations can facilitate timely intervention to delay or prevent T2DM onset. Metaboli...

2025-08-04 | MTBLS10965 | MetaboLights
TranscriptomicsCorrelation of Candidate Genetic Variations for Susceptibility and Risk Assessment of Type 2 Diabetes Mellitus and its Related Medical Conditions among Filipinos (DM2)
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-17413 | biostudies-arrayexpress
TranscriptomicsCorrelation of Candidate Genetic Variations for Susceptibility and Risk Assessment of Type 2 Diabetes Mellitus and its Related Medical Conditions among Filipinos (DM2)
Various studies have established the role of genetics in the development of type 2 diabetes mellitus (T2DM) across population groups with a reported heritability of 30–70%. These studies highlight the effect of interethnic variability in genetic susceptibility and risk for complications of T2DM. The...
ORGANISM(S): Homo sapiens 
2026-09-01 | E-MTAB-17412 | biostudies-arrayexpress
TranscriptomicsTrained and untrained human skeletal muscle single-nucleus RNA-sequencing from individuals with type 2 diabetes and control
Single-nuclei RNA sequencing (snRNA-seq) data of human muscle cells. The samples are a part of a study investigating the effect of one-legged high-intensity interval training (HIIT) on the nuclear transcriptional response in skeletal muscle. The HIIT was done on one leg on a cycle ergometer, and vas...
ORGANISM(S): Homo sapiens 
2025-04-24 | E-MTAB-15009 | biostudies-arrayexpress
ProteomicsQuantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries from Patients with Type 2 Diabetes and Lower Levels among Metformin Users
We analyzed non-atherosclerotic repair arteries gathered at coronary by-pass operations from 30 patients with type 2 diabetes, as well as from 30 age- and gender-matched non-diabetic individuals. Quantitative proteome analysis was done by iTRAQ-labelling and LC-MS/MS analysis on individual arterial ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080848 | MassIVE
ProteomicsThe human diabetes-specific visceral adipose tissue proteome: insights into mechanisms of adipose tissue dysfunction in metabolic disease
Introduction: The human adipose tissue proteome associated with type 2 diabetes (DM) is not well described. An understanding of the DM-specific adipose tissue proteome would provide insight into mechanisms underlying the pathogenesis of DM. Methods: We used label-free proteomics analysis to quanti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-03-27 | MSV000085169 | MassIVE
GenomicsGenetic sequencing of MODY patients.
Maturity-onset Diabetes of the young (MODY) is an early-onset, autosomal dominant form of non-insulin dependent diabetes. Genetic diagnosis of MODY can transform patient management. Earlier data on the genetic predisposition to MODY have come primarily from familial studies in populations of Europea...
EGAS00001001699 | EGA
MetabolomicsSalivary Multi-omics Characterization and Staging Diagnostic Model for Type 2 Diabetes with Different Stages of Periodontitis

Background: This study aims to comprehensively characterize the dynamic succession of the salivary microbiome and metabolic reprogramming in type 2 diabetes mellitus (T2DM) patients across progressive stages of periodontitis (Stage I–IV) using an integrated multi-omics approach. We specifica...

2026-05-20 | MTBLS13827 | MetaboLights
ProteomicsChanges in the proteome of human induced pluripotent stem cells derived endothelial cells with CRISPR/Cas9 induced monoallelic and biallelic mutation of the HNF1A gene
Maturity onset diabetes of the young (MODY) is caused by a mutation in a single gene and leads to diabetes under the age of 25. The mutations in HNF1A gene (leading to HNF1A-MODY) cause about 70% of all MODY cases. It was shown that patients with HNF1A-MODY often develop diabetic microvascular compl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-01 | PXD039471 | Pride
Maturity onset diabetes of the young Endothelial cells Hnf1a-mody Ipscs-ec 
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