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ProteomicsThe ubiquitin ligase Ariadne-1 regulates NSF for neurotransmitter release
The aim of the present project was to identify putative substrates of Ariadne-1 (Ari-1), an essential E3 ubiquitin-ligase, in Drosophila heads. For that purpose we combined an in vivo ubiquitin biotinylation strategy termed bioUb with label free mass spectrometry analysis. In brief, BioUb strategy r...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-02-09 | PXD022701 | Pride
Synapse E3 ubiquitin ligase Neurotransmitter release Ubiquitination Ariadne-1 Drosophila Nsf 
ProteomicsA proteomic approach for systematic mapping of human deubiquitinating enzymes substrates
In the present study we implemented the bioUb approach to identify DUB substrates in a systemic manner. DUBs have been individually silenced so that the ubiquitination levels of their respective substrates are increased, and hence, upon isolation, susbtrates have been detected by mass spectrometry. ...
ORGANISM(S): Homo sapiens (Human) 
2021-04-29 | PXD025443 | Pride
Deubiquitinating enzyme Bioub Substrate Dubase Database 
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
2024-06-18 | PXD053221 |
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