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Transcriptomicsmice mRNA array for MACF1-knockdown MC3T3-E1 cell line
MC3T3-E1 cells with stable knockdown of MACF1 by shRNA. Cells were normally cultured and RNA extracted for mRNA microarray.
ORGANISM(S): Mus musculus 
2022-02-02 | E-MTAB-11425 | biostudies-arrayexpress
Transcriptomicsmice lncRNA array for MACF1-knockdown MC3T3-E1 cell line
MC3T3-E1 cells with stable knockdown of MACF1 by shRNA. Cells were normally cultured and RNA extracted for lncRNA microarray.
ORGANISM(S): Mus musculus 
2022-02-11 | E-MTAB-11426 | biostudies-arrayexpress
TranscriptomicsTumor-derived Jagged1- and Notch-dependent transcription changes in MC3T3-E1 osteoblasts
Transcriptional profiling of MC3T3-E1 osteoblasts that were flow cytometry-separated from cocultures with control or Jagged1-overexpressing tumor cells and treated with either DMSO control or 1μM MRK-003 (gamma-secretase inhibitor). One cell line (MC3T3-E1) cells: four different experimental conditi...
ORGANISM(S): Mus musculus 
2010-08-15 | E-GEOD-20517 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse MC3T3-E1 preosteoblasts with HDIs (trichostatin A, MS-275, or valproic acid) or the vehicle control (DMSO) for 18 hours in osteogenic conditions
Background:; Osteoblast differentiation requires the coordinated stepwise expression of multiple genes. Histone deacetylase inhibitors (HDIs) accelerate the osteoblast differentiation process by blocking the activity of histone deacetylases (HDACs), which alter gene expression by modifying chromati...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9247 | biostudies-arrayexpress
GenomicsMus musculus strain:MC3T3-E1 Subclone 4
Mus musculus strain:MC3T3-E1 Subclone 4 Transcriptome or Gene expression
PRJNA233971 | ENA
ProteomicsCell surface proteome in MC3T3-E1 mouse osteoblast cells
Here, using proteomic analysis of MC3T3-E1 cells subjected to either sh-SCR control or sh-Snx17 knockdown, we provide a data-rich resource that reveals novel molecular insights into how SNX17 regulates the membrane proteome.
ORGANISM(S): Mus musculus (Mouse) 
2026-05-05 | PXD064783 | Pride
Snx17 Mc3t3-e1 Cell surface proteome Tmt label Lc-ms/ms 
TranscriptomicsGenomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation [gene expression]
The biological effects of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on osteoblast differentiation and function differ significantly depending upon the cellular state of maturation. To explore this phenomenon mechanistically, we examined the impact of 1,25(OH)2D3 on the transcriptomes of both pre-oste...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-51514 | biostudies-arrayexpress
MetabolomicsUntargeted LC–MS Metabolomic Analysis of Connexin 43 in Bone Metabolism

MC3T3-E1 cells were divided into two groups: si-NC and si-Connexin43. Cx43 expression was knocked down using siRNA transfection, followed by LC–MS-based untargeted metabolomic analysis to investigate metabolic alterations associated with Connexin 43 deficiency in osteoblasts and its potential rol...

2026-09-29 | MTBLS14532 | MetaboLights
TranscriptomicsIdentification of genes responsive to low-intensity pulsed ultrasound (LIPUS) in MC3T3-E1 preosteoblast cells
Although LIPUS has been shown to enhance fracture healing, the underlying mechanism of LIPUS remains to be fully elucidated. Here, to understand the molecular mechanism underlying cellular responses to LIPUS, we investigated gene expression profiles in mouse MC3T3-E1 preosteoblast cells using a Gene...
ORGANISM(S): Mus musculus 
2013-03-26 | E-GEOD-45487 | biostudies-arrayexpress
GenomicsSearch for PTH-induced genes in MC3T3-E1 cells
Search for PTH-induced genes in MC3T3-E1 cells
PRJNA966905 | ENA
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