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ProteomicsPrenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities
The bactericidal function of neutrophils are dependent on myriad intrinsic and extrinsic stimuli. Using systems immunology approaches we identified microbiome- and infection-induced changes in neutrophils. We focused on investigating the Prenylcysteine oxidase 1 like (Pcyox1l) protein function. Muri...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-14 | PXD031115 | Pride
Neutrophil Prenylation Pcyox1l 
ProteomicsPseudomonas aeruginosa proteome under hypoxic stress conditions mimicking the cystic fibrosis lung
Pseudomonas aeruginosa is a Gram-negative, opportunistic bacterium and a major etiological agent in monogenic disease cystic fibrosis (CF). High density colonies of P. aeruginosa are often isolated from hypoxic mucus plugs in respiratory tract of CF patients, indicating high adaptive capacities of t...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2017-08-29 | PXD007233 | Pride
Cystic fibrosis Hypoxia Pseudomonas aeruginosa Tmt-ms Swath-ms 
ProteomicsTYK2 inhibition reverses immune-mediated neural cell death triggered by cytoplasmic dsRNA, a damage associated molecular pattern present in Alzheimer’s Disease
Neuroinflammation is a pathological feature of distinct neurodegenerative diseases, including Alzheimer’s disease (AD) and ALS, raising the possibility of common therapeutic targets. We previously established that cytoplasmic double-stranded RNA (cdsRNA) is spatially coincident with cytoplasmic pTDP...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD043641 | Pride
UnknownWhole-Body Hypothermia for Neonatal Encephalopathy in Preterm Infants 33 to 35 Weeks' Gestation: A Randomized Clinical Trial.
Not available
S-EPMC11851295 | biostudies-literature
UnknownDuration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.
Not available
S-EPMC7616389 | biostudies-literature
UnknownAdding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Not available
S-EPMC7616360 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
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