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UnknownAssociations Between Episodic Memory and Hippocampal Volume in Late Adulthood.
Different tasks of episodic memory (EM) are only moderately correlated with each other. Furthermore, various EM tasks exhibit disproportional relationships with the hippocampus. This study examined the covariance structure of EM tasks and assessed whether this structure relates differently to hippoc...
S-EPMC12001747 | biostudies-literature
UnknownA second update on mapping the human genetic architecture of COVID-19.
Not available
S-EPMC10482689 | biostudies-literature
UnknownEffect of Lower Tidal Volume Ventilation Facilitated by Extracorporeal Carbon Dioxide Removal vs Standard Care Ventilation on 90-Day Mortality in Patients With Acute Hypoxemic Respiratory Failure: The REST Randomized Clinical Trial.

Importance

In patients who require mechanical ventilation for acute hypoxemic respiratory failure, further reduction in tidal volumes, compared with conventional low tidal volume ventilation, may improve outcomes.

Objective

To determine whether lower tidal volume mechanical ventilatio...
S-EPMC8408762 | biostudies-literature
UnknownFour novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo.
There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify ...
S-EPMC2965750 | biostudies-literature
UnknownBiomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.

Importance

For hospitalized critically ill adults with suspected sepsis, procalcitonin (PCT) and C-reactive protein (CRP) monitoring protocols can guide the duration of antibiotic therapy, but the evidence of the effect and safety of these protocols remains uncertain.

Objective

To det...
S-EPMC11862976 | biostudies-literature
UnknownDexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial.

Importance

Whether α2-adrenergic receptor agonist-based sedation, compared with propofol-based sedation, reduces time to extubation in patients receiving mechanical ventilation in the intensive care unit (ICU) is uncertain.

Objective

To evaluate whether dexmedetomidine- or clonidine-b...
S-EPMC12090071 | biostudies-literature
UnknownCost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis.

Background

Procalcitonin (PCT)-guided antibiotic duration for critically ill adults with sepsis may be clinically effective and safe. However, cost-effectiveness analyses using clinical trial data for this precision medicine approach in critical care are lacking. This economic evaluation inv...
S-EPMC12661845 | biostudies-literature
UnknownCost-Effectiveness of α2 Agonists for Intravenous Sedation in Patients With Critical Illness.

Importance

Propofol and the α2 agonists dexmedetomidine and clonidine are used for sedation in patients with critical illness receiving mechanical ventilation. Evidence about the cost-effectiveness of intravenous (IV) sedation with these medications is lacking.

Objective

To investigat...
S-EPMC12090026 | biostudies-literature
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited. Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and 5,347 popu...
S-EPMC11320601 | biostudies-literature
UnknownWhole-genome sequencing reveals host factors underlying critical COVID-19.
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2-4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enab...
S-EPMC9259496 | biostudies-literature
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