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TranscriptomicsA DNA polymerase ? accessory protein, Mcl1, is required for propagation of centromere structures in fission yeast
Specialized chromatin exists at centromeres and must be precisely transmitted during DNA replication. The mechanisms involved in the propagation of these structures remain elusive. Fission yeast centromeres are composed of two chromatin domains: the central CENP-ACnp1 kinetochore domain and flanking...
ORGANISM(S): Schizosaccharomyces pombe 
2008-07-22 | E-GEOD-11102 | biostudies-arrayexpress
TranscriptomicsMCL1 is deregulated in subgroups of diffuse large B-cell lymphoma
MCL1 is an anti-apoptotic member of the BCL2 family that is deregulated in various solid and hematological malignancies. However, its role in the molecular pathogenesis of diffuse large B-cell lymphoma (DLBCL) is unclear. We analyzed gene expression profiling data from 350 DLBCL patient samples and ...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-43272 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCL1 over-expressing B-NHL cells
To get insight into the mechanisms of MCL1-induced survival and transformation, we screened 41,000 human genes in a genome-wide gene expression profile analysis of MCL1 over-expressing B-NHL cells. Experiment Overall Design: Two-color (Cy5-CTP/ Cy3-CTP) microarray-based gene expression formats prese...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8834 | biostudies-arrayexpress
ProteomicsMCL1 may not mediate chemoresistance: HCT116 Data
HCT116 cells transiently over-expressing either TurboID-MCL1 (human, full-length) or the negative control TurboID-GFP were subjected to a proximity biotinylation workflow and enrichment to identify MCL1-specific interactors in live cells.
ORGANISM(S): Homo sapiens (Human) 
2026-08-27 | PXD082999 | Pride
Mcl1  turboid  proximity biotinylation 
ProteomicsMCL1 may not mediate chemoresistance: Hela Cells
HCT116 cells transiently over-expressing either TurboID-MCL1 (human, full-length) or the negative control TurboID-GFP were subjected to a proximity biotinylation workflow and enrichment to identify MCL1-specific interactors in live cells.
ORGANISM(S): Homo sapiens (Human) 
2026-08-27 | PXD083239 | Pride
Mcl1  turboid  proximity biotinylation 
TranscriptomicsMCL1 inhibitor induces apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma
Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignanices and contributes to leukemogenesis by inhibiting the apoptotic machinery of the cells. BH3 mimetics provide an option for medication, with venetoclax as the first drug applied for chronic lymphocytic leuke...
ORGANISM(S): Homo sapiens 
2021-12-31 | E-MTAB-10903 | biostudies-arrayexpress
ProteomicsIdentification of human MCL1 acetylation
The anti-apoptotic MCL1 protein is a member of the pro-survival BCL2 family and is frequently amplified or elevated in human cancers. MCL1 protein is highly unstable, with its stability being regulated by phosphorylation and ubiquitination. We attempted to identify acetylation as another critical po...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-14 | MSV000088231 | MassIVE
TranscriptomicsTranscription profiling of human CEM-C1 cells treate with rapamycin for 3 hours
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5822 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CEM_C1 cells after rapamycin treatment of 24 hours
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Acute Lymphoblastic Leukemia CEM_C1 cells treated with rapamycin identifies rapamycin as a glucocorticoid resistance reversal agent
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-11-06 | E-GEOD-5824 | biostudies-arrayexpress
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