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ProteomicsTargeting Ubiquitin-specific proteases (USP14) Reduces Metastatic Potential and Metabolic Activity in Cervical Cancer by Modulating MCT-4
Cervical cancer is the most common cancer among women worldwide, predominantly caused by human papillomavirus (HPV) subtypes, particularly HPV 16 and 18. Although it is largely preventable through vaccination and early detection, cervical cancer remains a significant health issue, particularly in lo...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD067901 | Pride
Chemoresistance Tcga Iu-1 inhibitor Lactate efflux Ubiquitin-specific proteases Mct-4 Molecular docking Metabolic reprogramming Usp14 Deubiquitinating enzymes (dubs) Proteomics Metastasis Cervical cancer 
TranscriptomicsMCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
Many cancers rely on glycolytic metabolism to fuel rapid proliferation. This has spurred interest in designing drugs that target tumor glycolysis such as AZD3965, a small molecule inhibitor of Monocarboxylate Transporter 1 (MCT1) currently undergoing Phase I evaluation for cancer treatment. Since ...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-76675 | biostudies-arrayexpress
UnknownRepurposing brucine as a chemopreventive agent in mammary gland carcinoma: Regulating lactate transport through MCT-4.
Not available
S-EPMC11787605 | biostudies-literature
TranscriptomicsGenomic alterations during the progress of pulmonary hypertension
Pulmonary hypertension (PH), a rare disorder is a complication of a number of cardiopulmonary, unrelated systemic diseases, drug toxicity and genetic mutations. Major advances have been made in the field, but the pathogenesis of PH is not yet understood. Several experimental models such as monocro...
ORGANISM(S): Rattus norvegicus 
2015-09-04 | E-GEOD-72707 | biostudies-arrayexpress
TranscriptomicsDoes Phosphatidylserine (PS) affect gene expression in FD mice?
Genes associated with transcription regulation and development processes were up-regulated in the cerebrum of PS-treated mice. at 4 months of age 6 FD mice were gavaged with either 200mg/kg PS (3 mice) or medium-chain triglycerides (MCT, 3 mice) every other day for a period of 3 months
ORGANISM(S): Mus musculus 
2013-04-02 | E-GEOD-45580 | biostudies-arrayexpress
ProteomicsQuantitative proteomic and phosphoproteomic profiling of lung and heart tissues from Pulmonary arterial hypertension model rats
TMT-based quantitative proteomics was performed on lung tissues derived from SD rats which were treated with monocrotaline （MCT） for 1to 4 weeks. Similar analysis was performed with RV tissues from rats treated with MCT for 3 weeks. In addition, phosphoproteomic analysis was performed with lung and ...
ORGANISM(S): Rattus Norvegicus 
2022-11-25 | PXD038462 |
UnknownHigh expression of monocarboxylate transporter 4 (MCT 4), but not MCT 1, predicts poor prognosis in patients with non-small cell lung cancer.
Not available
S-EPMC8798489 | biostudies-literature
TranscriptomicsGenomic alterations during the progress of pulmonary hypertension
Pulmonary hypertension (PH), a rare disorder is a complication of a number of cardiopulmonary, unrelated systemic diseases, drug toxicity and genetic mutations. Major advances have been made in the field, but the pathogenesis of PH is not yet understood. Several experimental models such as monocrota...
ORGANISM(S): Rattus norvegicus 
2015-09-04 | GSE72707 | GEO
TranscriptomicsMCT4 knockdown in pancreatic cancer cells
Gene expression levels were determined with control or MCT4 knockdown pancreatic cancer cells. MiaPaca2, Capan-2, and PL45 cells were transfected with non-specific or MCT4-specific RNAi. RNA was harvested at 72 hours post transfection and analyzed on Illumina microarrays.
ORGANISM(S): Homo sapiens 
2014-12-17 | E-GEOD-63231 | biostudies-arrayexpress
TranscriptomicsChemotherapy-mediated changes in the immune cell landscape of murine triple negative breast cancer.
We performed CITE-seq (10x Genomics-based) to profile and compare the transcriptomes and cell surface expression of immune epitopes in the primary breast tumors of transgenic mice (C3-1-TAg) with or without MCT chemotherapy. We sequenced a total of six different tumor samples. We created an antibody...
ORGANISM(S): Mus musculus 
2023-02-26 | GSE158888 | GEO
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