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TranscriptomicsMCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
Many cancers rely on glycolytic metabolism to fuel rapid proliferation. This has spurred interest in designing drugs that target tumor glycolysis such as AZD3965, a small molecule inhibitor of Monocarboxylate Transporter 1 (MCT1) currently undergoing Phase I evaluation for cancer treatment. Since ...
ORGANISM(S): Homo sapiens 
2016-03-08 | E-GEOD-76675 | biostudies-arrayexpress
ProteomicsFasting upregulates the monocarboxylate transporter Mct1 at the rat blood-brain barrier through Ppar d activation
Fasting is increasingly recognized as a potential therapeutic intervention in the field of neurology and psychiatry. However, its impact upon the blood-brain barrier (BBB), which strictly regulates the cerebral uptake of a wide range of endogenous compounds and drugs, is unknown. In this study we us...
ORGANISM(S): Cellular Organisms 
2024-08-15 | PXD044587 | JPOST Repository
GenomicsMCT1 deletion in Saccharomyces cerevisiae
MCT1 deletion in Saccharomyces cerevisiae
PRJNA636574 | ENA
TranscriptomicsMCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
Many cancers rely on glycolytic metabolism to fuel rapid proliferation. This has spurred interest in designing drugs that target tumor glycolysis such as AZD3965, a small molecule inhibitor of Monocarboxylate Transporter 1 (MCT1) currently undergoing Phase I evaluation for cancer treatment. Since MC...
ORGANISM(S): Homo sapiens 
2016-03-08 | GSE76675 | GEO
GenomicsTranscriptional changes in B cells induced by MCT1 depletion
Transcriptional changes in B cells induced by MCT1 depletion
PRJNA1036617 | ENA
ProteomicsMCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylation
Monocarboxylate transporter 1 (MCT1) exhibits essential roles in cellular metabolism and energy supply. Although MCT1 is highly expressed in activated B cells, it is not clear how MCT1-governed monocarboxylates transportation is functionally coupled to antibody production during the glucose metaboli...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-14 | PXD047325 | Pride
B cell Lc-ms/ms A20 Nuclei 
GenomicsChromatin accessibility by ATAC in wild type versus MCT1-knockout B cells
Chromatin accessibility by ATAC in wild type versus MCT1-knockout B cells
PRJNA1036615 | ENA
TranscriptomicsMCT1 deletion in Saccharomyces cerevisiae
MCT1 was deleted in Saccharomyces cerevisiae and gene expression was measured over a timecourse.
ORGANISM(S): Saccharomyces cerevisiae 
2020-06-02 | GSE151606 | GEO
ProteomicsA Pilot Proteogenomic Study With Data Integration Identifies MCT1 and GLUT1 as Prognostic Markers in Lung Adenocarcinoma
We performed a pilot proteogenomic study to compare lung adenocarcinoma to lung squamous cell carcinoma using quantitative proteomics (6-plex TMT) combined with a customized Affymetrix GeneChip. Using MaxQuant software, we identified 51,001 unique peptides that mapped to 7,241 unique proteins and fr...
ORGANISM(S): Homo sapiens (Human) 
2015-11-06 | PXD002622 | Pride
Non-small cell lung cancer Lung adenocarcinoma Tmt Mct1 Nsclc Lung squamous cell carcinoma Glut1 Proteogenomics Slc16a1 Slc2a1 
UnknownAstrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion.
Not available
S-EPMC12673003 | biostudies-literature
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