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GenomicsTranscriptional interference drives intronic polyadenylation at the endogenous H13/Mcts2 locus
Transcriptional interference drives intronic polyadenylation at the endogenous H13/Mcts2 locus
PRJNA1330887 | ENA
GenomicsTranscriptional interference drives intronic polyadenylation at the endogenous H13/Mcts2 locus
ABSTRACT: Over a tenth of mammalian genes are organised as nested within distinct host genes, questioning how both can be expressed when concurrent transcription can collide in the same genetic space. DNA methylation-mediated silencing of nested genes can prevent such conflict. Alternatively, transc...
ORGANISM(S): Mus musculus 
2026-06-11 | GSE308559 | GEO
ProteomicsIdentification of DENR-interacting proteins in NIH3t3 cells using a co-IP MS-MS approach on endogenously tagged DENR.
Among the transcript features that regulate translation rate, upstream open reading frames (uORFs) have emerged as a major class of inhibitory elements which limit how many scanning ribosomes reach the start codon of the main protein coding sequence (CDS). Two processes are implicated in ensuring th...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-01 | PXD051482 | Pride
Co-immunoprecipitation Denr Translation Mcts2 Mcts1 Re-initiation 
UnknownMCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays.
Not available
S-EPMC11790910 | biostudies-literature
UnknownA screen for retrotransposed imprinted genes reveals an association between X chromosome homology and maternal germ-line methylation.
Not available
S-EPMC1796624 | biostudies-literature
UnknownMCTS2 and distinct eIF2D roles in uORF-dependent translation regulation revealed by in vitro re-initiation assays
Not available
S-SCDT-10_1038-S44318-024-00347-3 | biostudies-other
UnknownImprinting methylation predicts hippocampal volumes and hyperintensities and the change with age in later life.
Not available
S-EPMC7806645 | biostudies-literature
Methylation profilingArray-based DNA-methylation analysis in individuals with developmental delay/intellectual disability and normal molecular karyotype
We analyzed the DNA methylation of peripheral blood samples from 81 individuals with intellectual disability (ID) and compared this methylation pattern to 19 normal controls using the HumanMethylation450 BeadChip and bisulfite pyrosequencing for validiation. We could not show a global methylation pa...
ORGANISM(S): Homo sapiens 
2015-06-03 | GSE64380 | GEO
Methylation profilingTET3 regulates cellular identity and DNA methylation in neural progenitor cells
TET enzymes oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), a process thought to be intermediary in an active DNA demethylation mechanism. Notably, 5hmC is highly abundant in the brain and in neuronal cells. Here we show that Tet3 is highly upregulated during neuronal differentia...
ORGANISM(S): Mus musculus 
2019-09-23 | GSE123110 | GEO
UnknownA case-by-case evolutionary analysis of four imprinted retrogenes.
Not available
S-EPMC3107425 | biostudies-literature
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