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TranscriptomicsSingle-Stranded Annealing Induced by Re-Initiation of Replication Origins Provides a Novel and Efficient Mechanism for Generating Copy Number Expansion via Non-Allelic Homologous Recombination.
Copy number expansions such as amplifications and duplications contribute to human phenotypic variation, promote molecular diversification during evolution, and drive the initiation and/or progression of various cancers. The mechanisms underlying these copy number changes are still incompletely unde...
ORGANISM(S): Saccharomyces cerevisiae 
2013-01-04 | E-GEOD-41259 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. pombe reveals Cyclin dependent kinase inhibits re-initiation of a normal S-phase program during G2
To achieve faithful replication of the genome once in each cell cycle, re-initiation of S-phase is prevented in G2 and origins are restricted from re-firing within S-phase. We have investigated the block to re-replication during G2 in fission yeast. The DNA synthesis that occurs when G2/M cyclin d...
ORGANISM(S): Schizosaccharomyces pombe 
2009-05-13 | E-MTAB-105 | biostudies-arrayexpress
ProteomicsIdentification of DENR-interacting proteins in NIH3t3 cells using a co-IP MS-MS approach on endogenously tagged DENR.
Among the transcript features that regulate translation rate, upstream open reading frames (uORFs) have emerged as a major class of inhibitory elements which limit how many scanning ribosomes reach the start codon of the main protein coding sequence (CDS). Two processes are implicated in ensuring th...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-01 | PXD051482 | Pride
Co-immunoprecipitation Denr Translation Mcts2 Mcts1 Re-initiation 
GenomicsRegulatory Mechanisms That Prevent Re-initiation of DNA Replication Can Be Locally Modulated at Origins by Nearby Sequence Elements
Eukaryotic cells must inhibit re-initiation of DNA replication at each of the thousands of origins in their genome because re-initiation can generate genomic alterations with extraordinary frequency. To minimize the probability of re-initiation from so many origins, cells use a battery of regulatory...
ORGANISM(S): Saccharomyces cerevisiae 
2014-03-15 | GSE55420 | GEO
GenomicsCDK7 inhibition suppresses RNA polymerase II re-initiation and triggers degradation of elongation and 3'-end processing factors
CDK7 inhibition suppresses RNA polymerase II re-initiation and triggers degradation of elongation and 3'-end processing factors
PRJNA1117577 | ENA
GenomicsRibosome profiling analysis of Denr and Eif2d depleted cells reveals the absence of re-initiation function of EIF2D
Ribosome profiling analysis of Denr and Eif2d depleted cells reveals the absence of re-initiation function of EIF2D
PRJNA1100515 | ENA
UnknownRequirements for translation re-initiation in Escherichia coli: roles of initiator tRNA and initiation factors IF2 and IF3.
Not available
S-EPMC2268962 | biostudies-literature
GenomicsAsymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells
Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells
PRJNA1207541 | ENA
UnknownDENR-MCT-1 promotes translation re-initiation downstream of uORFs to control tissue growth.
Not available
S-EPMC4134322 | biostudies-literature
GenomicsGenome-wide Analysis of Re-replication Reveals Inhibitory Controls that Target Multiple Stages of Replication Initiation
DNA replication must be tightly controlled during each cell cycle to prevent unscheduled replication and ensure proper genome maintenance. The currently known controls that prevent re-replication act redundantly to inhibit pre-Replicative Complex (pre-RC) assembly outside of the G1 phase of the cell...
ORGANISM(S): Saccharomyces cerevisiae 
2006-03-20 | GSE4487 | GEO
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