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ProteomicsIdentification of DENR-interacting proteins in NIH3t3 cells using a co-IP MS-MS approach on endogenously tagged DENR.
Among the transcript features that regulate translation rate, upstream open reading frames (uORFs) have emerged as a major class of inhibitory elements which limit how many scanning ribosomes reach the start codon of the main protein coding sequence (CDS). Two processes are implicated in ensuring th...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-01 | PXD051482 | Pride
Co-immunoprecipitation Denr Translation Mcts2 Mcts1 Re-initiation 
TranscriptomicsPolysomes from DENR knockdown cells
The aim was to identify transcripts that are poorly translated upon knockdown of DENR. Lysates from control (GFP) and DENR knockdown S2 cells were run on polysome gradients. RNA from the (80S peak + polysome peaks) was isolated and analyzed by microarrays. In parallel, total RNA from the cells was a...
ORGANISM(S): Drosophila melanogaster 
2014-06-30 | E-GEOD-54625 | biostudies-arrayexpress
TranscriptomicsPolysomes from DENR knockdown cells
The aim was to identify transcripts that are poorly translated upon knockdown of DENR. Lysates from control (GFP) and DENR knockdown S2 cells were run on polysome gradients. RNA from the (80S peak + polysome peaks) was isolated and analyzed by microarrays. In parallel, total RNA from the cells was a...
ORGANISM(S): Drosophila melanogaster 
2014-06-30 | GSE54625 | GEO
GenomicsMaster stress response gene ATF4 & other oncogenes are translated by DENR-dependent reinitiation
Master stress response gene ATF4 & other oncogenes are translated by DENR-dependent reinitiation
PRJNA588223 | ENA
GenomicsDENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion
DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion
PRJNA762565 | ENA
UnknownCrystal structure of the C-terminal domain of DENR.
Not available
S-EPMC7114459 | biostudies-literature
UnknownDENR-MCTS1 heterodimerization and tRNA recruitment are required for translation reinitiation.
Not available
S-EPMC6013234 | biostudies-literature
GenomicsDENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion [CRISPR screen]
DENR controls JAK2 translation to induce PD-L1 expression for tumor immune evasion [CRISPR screen]
PRJNA762899 | ENA
TranscriptomicsMaster stress response gene ATF4 & other oncogenes are translated by DENR-dependent reinitiation
Translation efficiency varies 1000-fold between different mRNAs, thereby strongly impacting protein expression. Translation of the master stress response gene ATF4 increases in response to stress, but the molecular mechanisms are not well understood. We discover here that translation initiation fact...
ORGANISM(S): Homo sapiens 
2020-07-18 | GSE140084 | GEO
UnknownCrystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Not available
S-EPMC5551485 | biostudies-literature
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