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ProteomicsThe melanoma cell line MDA-MB-435 adhesome in long-term culture and its comparison to the adhesome upon integrin αV knockdown
Using mass spectrometry–based proteomics, we analysed the components of integrin adhesion complexes of MDA-MB-435S cells and two MDA-MB-435S-derived integrin αV-specific shRNA-expressing cell clones. Among integrins, we detected αV and β5 integrin subunits in the MDA-MB-435S adhesome, thus showing t...
ORGANISM(S): Homo sapiens (Human) 
2020-02-17 | PXD016837 | Pride
Human Cancer Mda-mb-435s Integrin adhesion complex Adhesome Integrin αvβ5 Melanoma Cortical microtubule stabilisation complex 
ProteomicsThe composition of reticular adhesions in RPMI-7951 and MDA-MB-435S melanoma cell lines and its comparison with the reticular adhesion composition following talin2 or KANK2 knockdown
Integrins bind extracellular matrix proteins and, when clustered, form integrin adhesion complexes (IACs) that connect to and regulate the cytoskeleton, shaping normal and tumour cell behaviour. In addition to well-known nascent adhesions, focal adhesions (FAs), fibrillar adhesions (FBs), and hemide...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD071922 | Pride
Reticular adhesions Kank2 Matrisome Adhesome Melanoma Rpmi-7951 cells Integrin alphavbeta5 Talin2 Mda-mb-435s cells 
UnknownIncreased Expression of CD81 in Breast Cancer Tissue is Associated with Reduced Patient Prognosis and Increased Cell Migration and Proliferation in MDA-MB-231 and MDA-MB-435S Human Breast Cancer Cell Lines In Vitro.
Not available
S-EPMC6109364 | biostudies-literature
UnknownTalin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line.
Not available
S-EPMC10353188 | biostudies-literature
TranscriptomicsNext Generation Sequencing of MCF-7 and MDA-MB-435 cells
Human breast cancer cells MDA-MB-435 had higher metastatic potential and other aggressive characteristics than MCF-7 cells. Next-generation RNA sequencing (RNA-Seq) was used to clear this concern through comparison the transcriptomic expression profiles of these two cells. Total RNA were extracted ...
ORGANISM(S): Homo sapiens 
2014-01-17 | E-GEOD-54122 | biostudies-arrayexpress
TranscriptomicsEffects of YB-1 protein reduction on microRNA abundance in breast cancer cell-lines
To assess the association of the nucleic acid binding protein yb-1 with mature microRNAs levels in breast cancer. To do this we performed YB-1 siRNA treatement in triplicates alongside an siRNA control Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used, ...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50087 | biostudies-arrayexpress
TranscriptomicsEffect of GRPR activation on gene expression in human melanoma cells
To investigate the consequences of GRPR activation on the cell signaling, Dauv-1, MDA-MB-435S and 501-Mel GRPR human GRPRpos melanoma cell line were treated with GRPR agonist (GRP) and/or antagonist (RC-3095) and gene expression was analysed after four hours of stimulation in low serum conditions.
ORGANISM(S): Homo sapiens 
2025-04-21 | GSE218530 | GEO
TranscriptomicsIdentification of miRNAs which bind to YB-1 protein
To assess the direct association of the nucleic acid binding protein yb-1 with mature microRNAs in breast cancer. To do this we performed immunoprecipitation (IP) of YB-1 protein to pull-down linked RNAs Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used...
ORGANISM(S): Homo sapiens 
2014-01-23 | E-GEOD-50141 | biostudies-arrayexpress
TranscriptomicsExpression data from breast cancer cell lines with various colony-forming ability
Cultured cancer cells exhibit substantial phenotypic heterogeneity when measured in a variety of ways such as sensitivity to drugs or the capacity to grow under various conditions. Among these, the ability to exhibit anchorage-independent cell growth (colony forming capacity in semisolid media), ha...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-15026 | biostudies-arrayexpress
UnknownKANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration.
Not available
S-EPMC7063070 | biostudies-literature
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