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ProteomicsMDGA2 constrains the BDNF/TrkB signaling
MDGA2 is an excitatory synaptic suppressor and its mutations have been associated with autism spectrum disorder (ASD). However, the detailed physiological function of MDGA2 and the mechanism underlying MDGA2 deficiency-caused ASD has yet to be elucidated. Herein, we not only confirm that Mdga2+/- mi...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-06 | PXD050810 | Pride
Asd Mdga2 Bdnf Trkb 
UnknownContrastsing synaptic roles of MDGA1 and MDGA2.
Not available
S-EPMC10503827 | biostudies-literature
UnknownRPS23RG1 inhibits SORT1-mediated lysosomal degradation of MDGA2 to protect against autism.
Not available
S-EPMC11729561 | biostudies-literature
UnknownMdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice.
Not available
S-EPMC11960969 | biostudies-literature
TranscriptomicsLaf4/Aff3 is required for normal neuronal migration
The aim of this study was to investigate the function of Laf4 in the brain by focusing on its role in the developing cortex. By manipulating expression levels in organotypic slices, we demonstrate that Laf4 is required for normal cellular migration in the cortex and have subsequently identified Mdga...
ORGANISM(S): Mus musculus 
2014-07-01 | E-MTAB-2520 | biostudies-arrayexpress
UnknownMDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms.
Not available
S-EPMC11214077 | biostudies-literature
UnknownFunctional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Not available
S-EPMC11405390 | biostudies-literature
UnknownLaf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex.
Not available
S-EPMC4146563 | biostudies-literature
TranscriptomicsPotential involvement of KANK1 haploinsufficiency in centrosome aberrations
KANK1 was found as a tumor suppressor gene based on frequent deletions in renal cell carcinoma and the inhibitory activity of tumor cell proliferation. Previously, we reported that knockdown of KANK1 induced centrosomal amplification, leading to abnormal cell division, through the hyperactivation of...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE233700 | GEO
UnknownIdentification of Rare Variants in Metabolites of the Carnitine Pathway by Whole Genome Sequencing Analysis.
Not available
S-EPMC5609480 | biostudies-literature
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