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TranscriptomicsTwist, Snail and Zeb1 targets in the context of TrkB
RK3E cells expressing TrkB and BDNF: comparison control (sh-EGFP) and sh-Twist, sh-Snail or sh-Zeb1
ORGANISM(S): Rattus norvegicus 
2011-10-12 | E-MTAB-456 | biostudies-arrayexpress
TranscriptomicsBulk RNA-sequencing of C57BL/6J bone marrow stromal cells stained with anti-Neo1 or anti-TrkB antibodies
The aim of this study was to investigate mouse bone marrow stromal cells expressing cell-surface Neo1 or TrkB. For this, we isolated cells from digested bone, depleted hematopoietic populations, and performed FACS for subsequent low-input total RNA-sequencing. We compared gene expression profiles of...
ORGANISM(S): Mus musculus 
2026-08-14 | E-MTAB-17326 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat RK3E and RIE cells overexpressing activated TrkB
Overexpression of activated TrkB in RIE and RK3E cells
ORGANISM(S): Rattus norvegicus 
2010-02-27 | E-NCMF-21 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human neurons derived from mutant embryonic stem cell line lacking the BDNF receptor TrkB treated with the natural TrkC receptor agonist Neurotrophin-3
RNAseq data indicate that in the human brain, most neurons co-express the brain-derived neurotrophic factor (BDNF) receptor TrkB and the Neurotrophin-3 (NT3) receptor TrkC. Because NT3 can also activate TrkB and TrkB is expressed at higher levels compared with TrkC, it has been difficult thus far to...
ORGANISM(S): Homo sapiens 
2022-03-22 | E-MTAB-11566 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human neurons derived from H9 embryonic stem cell lines treated with BDNF, TrkB agonist ZEB 85 or NT4 against untreated controls
As a result of a large number of in vitro as well as in vivo experiments with rodents, brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB are now widely appreciated to play major roles in brain function. There is also a growing appreciation that decreased BDNF signalling ...
ORGANISM(S): Homo sapiens 
2018-07-13 | E-MTAB-6975 | biostudies-arrayexpress
ProteomicsMDGA2 constrains the BDNF/TrkB signaling
MDGA2 is an excitatory synaptic suppressor and its mutations have been associated with autism spectrum disorder (ASD). However, the detailed physiological function of MDGA2 and the mechanism underlying MDGA2 deficiency-caused ASD has yet to be elucidated. Herein, we not only confirm that Mdga2+/- mi...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-06 | PXD050810 | Pride
Asd Mdga2 Bdnf Trkb 
MetabolomicsHuman umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF/TrkB/CREB signaling pathway in aged mice

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

2023-07-25 | MTBLS7759 | MetaboLights
TranscriptomicsTranscription profiling of rat RK3E cells overexpressing activated TrkB following retroviral silencing of Fra-1
Silencing of Fra-1 in RK3E cells overexpressing activated TrkB
ORGANISM(S): Rattus norvegicus 
2009-04-29 | E-NCMF-20 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of neuronal differentiation in two subtypes of SH-SY5Y
Background: SH-SY5Y cells exhibit a neuronal phenotype when treated with all-trans retinoic acid (RA), but the molecular mechanism of activation in the signaling pathway mediated by phosphatidylinositol 3-kinase (PI3K) is not sufficiently understood. To shed new light on the mechanism, we comprehens...
ORGANISM(S): Homo sapiens 
2009-09-04 | E-GEOD-9169 | biostudies-arrayexpress
ProteomicsBDNF-TrkB signaling orchestrates the buildup process for local sleep
Using pharmacology and optogenetics perturbations, we showed that cortical brain-derived neurotrophic factor (BDNF) regulates the intensity of SWA via the activation of Tyrosine kinase B (TrkB) receptor and cAMP-response element-binding protein (CREB). We identified that the circuitry mediating TrkB...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-22 | PXD045652 | Pride
Circadian Bdnf Sleep homeostasis Creb Trkb Local sleep 
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