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MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
TranscriptomicsCREB ChIP-chip and HaloCHIP-chip experiments
Regulation of gene expression is essential for normal development and cellular growth. Transcriptional events are tightly controlled both spatially and temporally by specific DNA-protein interactions. In this study we finely map the genome-wide targets of the CREB protein across all known and predi...
ORGANISM(S): Homo sapiens 
2010-05-22 | E-GEOD-18347 | biostudies-arrayexpress
TranscriptomicsUltrastructural and transcriptional profiling of neuropathological misregulation of CREB function
We compare here the neurodegenerative processes observed in the hippocampus of bitransgenic mice with chronically altered levels of cAMP-response element-binding protein (CREB) function. The combination of genome-wide transcriptional profiling of degenerating hippocampal tissue with microscopy analy...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21137 | biostudies-arrayexpress
GenomicsIL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-64844 | biostudies-arrayexpress
Proteomicsproteins pulled down by CREB, part 2
Hepatocarcinoma is the third leading cause of death in cancer in the world. In recent years, research on CREB in hepatocellular carcinoma has become a hotspot, so our research group wants to use the mass spectrometry analysis what proteins can bind with CREB, and then explore the links between CREB ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD008261 | Pride
Lc-msms 
TranscriptomicsHypermethylation of miR-34b is associated with CREB overexpression and Myeloid Cell Transformation
Increased CREB levels and upregulation of its target genes expression resulted in increased myelopoiesis and colony formation. Class comparison between MDS patients at diagnosis and evolution in AML
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-25300 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse VP16-CREB transgenics
Expression of VP16-CREB, a constitutively active form of CREB, in hippocampal neurons of the CA1 region lowers the threshold for eliciting the late, persistent phase of long-term potentiation (L-LTP) in the Schaffer collateral pathway. This VP16-CREB-mediated L-LTP differs from the conventional late...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-3965 | biostudies-arrayexpress
TranscriptomicsStriatal microRNA controls cocaine intake through CREB signalling
MicroRNAs (miRNAs) regulate many basic aspects of cell biology including neuronal plasticity, but little is known of their roles in drug addiction. Extended access to cocaine can trigger the emergence of compulsive drug-seeking behaviors, but molecular mechanisms regulating this process remain uncle...
ORGANISM(S): Rattus norvegicus 
2010-07-08 | E-GEOD-21901 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat nucleus accumbens shell shows CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
We are comparing the gene expression patterns from rats in which they are either double housed or socially isolated. Within these groups we performed the following manipulations:

AAV-GFP to the NAc shell

AAV-CREB to the NAc shell

chronic imipramine treatment

water contro...
ORGANISM(S): Rattus norvegicus 
2009-01-01 | E-MEXP-1944 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of CREB knockdown in Acute Lymphoblastic Leukemia cells
Gene expression profiling was performed to examine genetic consequences that resulted from shRNA mediate knockdown of CREB in the four ALL cell lines Jurkat, Nalm6, Molt4, and RS4;11 using two CREB shRNAs. Leukemic cells were incubated with lentiviral supernatants for one or two consecutive days aft...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-68413 | biostudies-arrayexpress
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