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MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
ProteomicsQuantitative Proteomics Illuminates A Functional Interaction Between Mouse Homolog Of Diaphanous 2 (mDia2) And The Proteasome
Formin mDia2 is a cytoskeleton-regulatory protein that switches reversibly between a closed, auto-inhibited and an open, active conformation. Although the open conformation of mDia2 induces actin assembly thereby controlling many cellular processes, mDia2 possesses also actin-independent and conform...
ORGANISM(S): Homo sapiens (Human) 
2016-12-14 | PXD002066 | Pride
Human Hela Mdia2 Proteasome Ubiquitin 
ProteomicsProteomic analysis uncover a new function and mode of action for mDia2
mDia2 is an auto-inhibited Formin influencing actin dynamics upon conversion to the active conformation. mDia2 regulates actin-based protrusions and cell invasion, cell differentiation, vesicle trafficking and cytokinesis. However, whether mDia2 has additional functions and how its action is functio...
ORGANISM(S): Homo sapiens (Human) 
2015-01-06 | PXD000175 | Pride
Ap-ms Proteomics Mdia2 
TranscriptomicsGene Expression Profiles in erythroblasts and progenitor cells of mDia2 conditional KO mice
The goal of this study is to investigate the transcriptional network regulated by DIAPH3 gene (mDia2) using the conditional hematopoietic specific knockout mouse model, especially in the cell proliferation, cell survive (including oxidative stress), cell adhesion & migration, cell cycle and hematopo...
ORGANISM(S): Mus musculus 
2015-04-30 | E-GEOD-68422 | biostudies-arrayexpress
UnknownDiaphanous formin mDia2 regulates CENP-A levels at centromeres.
Not available
S-EPMC4878093 | biostudies-literature
UnknownEna/VASP regulates mDia2-initiated filopodial length, dynamics, and function.
Not available
S-EPMC4148250 | biostudies-literature
UnknownRho and anillin-dependent control of mDia2 localization and function in cytokinesis.
Not available
S-EPMC2938385 | biostudies-literature
UnknownA paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming.
Not available
S-EPMC7136968 | biostudies-literature
UnknownAn mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids.
Not available
S-EPMC3938721 | biostudies-literature
UnknownUbiquitin-mediated degradation of the formin mDia2 upon completion of cell division.
Not available
S-EPMC2740432 | biostudies-literature
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