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ProteomicsReduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
The two murine double minute (MDM) family members, MDM2 and MDMX are a well-established negative regulator of p53 activity. Under DNA damage conditions, MDM2 and MDMX are phosphorylated near their RING domains (serine 395 at MDM2 and serine 403 at MDMX) and switch to act as p53 positive regulators. ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD060074 | Pride
Human Mdmx-mdm2 interaction P53 mrna stabilization Ring domain Hdx-ms mapping Lc-ms/ms 
GenomicsMDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
PRJNA692186 | ENA
ProteomicsProteomic studies of human placentas reveal partnerships associated with preeclampsia, diabetes, gravidity, and labor
VEGFR2 (Vascular endothelial growth factor receptor 2) is a central regulator of placental angiogenesis. The study of the VEGFR2 proteome of chorionic villi at term revealed its partners MDMX (Double minute 4 protein) and PICALM (Phosphatidylinositol-binding clathrin assembly protein). Subsequently,...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD050049 | Pride
Vegfr2 Placenta Hofbauer cells Mdmx Trim21 Picalm Oxytocin receptor Proteomics 
GenomicsMicroarray of MDMX C462A and wildtype mice treated with acetaminophen
Microarray of MDMX C462A and wildtype mice treated with acetaminophen
PRJNA655235 | ENA
ProteomicsAnalysis of p53 independent functions of the Mdm2 MdmX complex using data independent acquisition based profiling
We utilized data independent acquisition (DIA) to study the poorly understood biology of Mdm2 and MdmX in a p53 null context. Mdm2 and MdmX form a E3 ligase complex that has as its most well studied function the negative regulation of the tumor suppressor p53, however, it is also known to interact w...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-12-05 | MSV000093577 | MassIVE
TranscriptomicsMDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism
The p53 inhibitor MDMX is overexpressed in the vast majority of patients with acute myeloid leukemia (AML). Utilizing hematopoietic stem cells from four non-leukemic/pre-leukemic murine models, we performed bulk transcriptomic analysis to evaluate the impact of Mdmx overexpression.
ORGANISM(S): Mus musculus 
2021-01-14 | GSE164838 | GEO
UnknownMDMX elevation by a novel Mdmx-p53 interaction inhibitor mitigates neuronal damage after ischemic stroke.
Not available
S-EPMC9726886 | biostudies-literature
GenomicsEffect of depletion of MDMX (aka MDM4) on gene expression in uveal melanoma cell line MEL202
Effect of depletion of MDMX (aka MDM4) on gene expression in uveal melanoma cell line MEL202
PRJNA872149 | ENA
UnknownThe MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX.
Not available
S-EPMC9644833 | biostudies-literature
UnknownDNA damage-induced phosphorylation of MdmX at serine 367 activates p53 by targeting MdmX for Mdm2-dependent degradation.
Not available
S-EPMC1265801 | biostudies-literature
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