Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse naive and tolerant macrophages treated with MDP- and Pam3CSK4
Most of the genes were self-tolerized by Pam3CSK4 and MDP but there was no or minimal cross-tolerization. The transcriptome induced via Nod2 stimulation is greatly expanded in TLR2-tolerant macrophages. Experiment Overall Design: Genes induced by Pam3CSK4 or MDP were selected based on a three-fold i...
ORGANISM(S): Mus musculus 
2008-04-05 | E-GEOD-10182 | biostudies-arrayexpress
TranscriptomicsExpression analysis of human PBMCs stimulated with Borrelia, MDP or Pam3cys.
Analysis examining the effect of the Crohn's disease-associated ATG16L1 polymorphism on the responses to stimulation components derived from various bacteria classes. Expression analysis was performed on RNA extracted from peripheral blood mononuclear cells (PBMCs) from healthy genotyped volunteers ...
ORGANISM(S): Homo sapiens 
2015-06-30 | E-GEOD-68765 | biostudies-arrayexpress
ProteomicsMDP phosphorylation by NAGK is essential for NOD2 activation
Bacterial cell wall components provide various unique molecular structures that are detected by pattern recognition receptors (PRRs) of the innate immune system as non-self. Most bacterial species form a cell wall that consists of peptidoglycan, a polymeric structure comprising of alternating amino ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-06-13 | PXD022384 | Pride
Nagk Sugar kinase Inflammation Muramyl dipeptide Nod2 Bacterial sensing 
TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
TranscriptomicsBone marrow derived dendritic cells (BMDC) and MDP and MSU
Muramyl dipeptide (MDP) and Monosodium urate crystals (MSU) promote a synergistic effect on NOD2 and NLRP3 with a unique transcriptional profile in murine dendritic cells
ORGANISM(S): Mus musculus 
2010-12-01 | E-MEXP-2905 | biostudies-arrayexpress
ProteomicsPeptidoglycan metabolite photoaffinity reporters reveal direct binding to intracellular pattern recognition receptors and Arf GTPases
Extensive structure-activity studies of iE-DAP and MDP have demonstrated their selective activation of NOD1- and NOD2-expressing cells, respectively. Nonetheless, the direct binding of iE-DAP and MDP to NOD1 and NOD2, respectively, as well as other proteins in mammalian cells has not been systematic...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD012350 | Pride
Mdp Gel-based proteomics Nod2 Hek293t 
TranscriptomicsThe acute transcriptional response of the coral Acropora millepora to immune challenge: expression of GiMAP/IAN genes links the innate immune response of corals with those of mammals and plants
This studies investigates the acute response of the coral Acropora millepora to two immunogenes: MDP (bacterial mimic) and pIC (viral mimic). Three members of the GiMAP familly were found to respond strongly to MDP treatment, showing analalogy to the immune response in vertebrates and plants. Differ...
ORGANISM(S): Acropora millepora 
2013-11-05 | E-GEOD-46389 | biostudies-arrayexpress
TranscriptomicsTranscriptome response after addition of individual agonists of TLR4 (MPLA) and NOD2 (MDP) receptors to THP-1 cells or its combination
Using microarray analysis, we explored the differences in gene expression profiles between individual and combined stimulation of Toll-like receptor 4 (TLR4) and Nucleotide oligomerization domain (NOD)-like receptor (NOD2) in THP-1 cells. Analysis was performed 3 hours post addition of TLR4 agonist...
ORGANISM(S): Homo sapiens 
2016-04-05 | E-GEOD-79900 | biostudies-arrayexpress
TranscriptomicsLiver expression data from 31 mouse strains treated with vehicle or isoniazid for 3 days
Isoniazid induced varying degrees of hepatic steatosis in an inbred strain Mouse Diversity Panel (MDP) study. RNA was isolated from all animals for analysis of gene expression changes in the liver. The objective of this study was to identify gene expression changes that drive isoniazid-induced steat...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-55489 | biostudies-arrayexpress
TranscriptomicsLiver expression data from four mouse strains treated with vehicle or PF-04287881 for seven days
PF-04287881 induced varying degrees of liver necrosis and phospholipidosis in a 34-inbred strain Mouse Diversity Panel (MDP) study. Four strains with differing susceptibilities to these phenotypes (MA/MyJ, NZW/LacJ, SM/J, WSB/EiJ) were selected for analysis of gene expression changes in the liver. T...
ORGANISM(S): Mus musculus 
2016-10-21 | E-GEOD-52620 | biostudies-arrayexpress
Sort   by:  
 Page size