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TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | E-GEOD-50707 | biostudies-arrayexpress
MetabolomicsSparing of muscle mass and function by passive loading in an experimental intensive care unit model
Not available
ORGANISM(S): Rattus norvegicus 
ST000165 | MetabolomicsWorkbench
TranscriptomicsGene expression patterns in bone following mechanical loading
The advent of high-throughput measurements of gene expression and bioinformatics analysis methods offers new ways to study gene expression patterns. The primary goal of this study was to determine the time sequence for gene expression in a bone subjected to mechanical loading, during key periods of...
ORGANISM(S): Rattus norvegicus 
2010-06-12 | E-GEOD-22286 | biostudies-arrayexpress
ProteomicsMechanical loading modulates AMPK and mTOR signaling in myoblasts
Skeletal muscle adaptation to exercise involves various phenotypic changes that enhance metabolic and contractile functions. One key regulator of these adaptive responses is the activation of AMPK, influenced by exercise intensity. However, the mechanistic understanding of AMPK activation during exe...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD050925 | Pride
Lc-ms L6 muscle cells Mechanical loading 
TranscriptomicsDifferential gene expression from microarray analysis distinguishes woven and lamellar bone formation in the rat ulna following mechanical loading
The objective of our study was to use a microarray to distinguish the molecular responses between woven and lamellar bone formation induced through mechanical loading. The micorarray identified numerous genes and pathways that were differentially regulated for woven, but not lamellar bone formati...
ORGANISM(S): Rattus norvegicus 
2013-01-01 | E-GEOD-27065 | biostudies-arrayexpress
TranscriptomicsThe ion channel Trpc6a regulates the cardiomyocyte regenerative response to mechanical stretch
Myocardial damage caused for example by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to...
ORGANISM(S): Danio rerio 
2023-12-20 | E-MTAB-13603 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiles in Engineered Cardiac Tissues Respond to Mechanical Loading and Inhibition of Tyrosine Kinase
Engineered cardiac tissues (ECTs) are platforms to investigate cardiomyocyte maturation and functional integration, to evaluate the feasibility of generating implantable tissues for cardiac repair and regeneration, and may be useful models for pharmacology and toxicology bioassays. These ECTs rapid...
ORGANISM(S): Rattus norvegicus 
2016-06-25 | E-GEOD-48342 | biostudies-arrayexpress
GenomicsRapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading
Rapgef3 modulates macrophage reprogramming and exacerbates synovitis and osteoarthritis under excessive mechanical loading
PRJNA1177415 | ENA
GenomicsMechanical Loading remodels transcriptional regulation in Osteocytes through Nucleus translocation of NRF2 [RNA-seq]
Mechanical Loading remodels transcriptional regulation in Osteocytes through Nucleus translocation of NRF2 [RNA-seq]
PRJNA1142070 | ENA
TranscriptomicsMechanical loading and gene expression - Microarray study
Skeletal integrity in humans and animals is maintained by daily mechanical loading. It has been widely accepted that osteocytes function as mechanosensors. Many biochemical signaling molecules are involved in the response of osteocytes to mechanical stimulation. The aim of this study was to identify...
ORGANISM(S): Rattus norvegicus 
2013-11-21 | GSE50707 | GEO
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