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TranscriptomicsFormalin Fixation at Low Temperature Better Preserves Nucleic Acid Integrity
INTRODUCTION. Fixation with formalin, a widely adopted procedure to preserve tissue samples, leads to extensive degradation of nucleic acids and thereby compromises procedures like microarray-based gene expression profiling. We hypothesized that RNA fragmentation is caused by activation of RNAses du...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-27175 | biostudies-arrayexpress
TranscriptomicsIdentification of p130Cas/ErbB2 dependent invasive signatures in transformed mammary epithelial cells.
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is over-expressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Ca...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-43907 | biostudies-arrayexpress
TranscriptomicsThe MET oncogene is a functional marker of a glioblastoma stem cell subtype and drives the invasive phenotype
Eighteen independent neurospheres derived from patients affected by primary glioblastoma were grouped into “classical”, “mesenchymal” or “proneural” subtypes according to analysis of genetic lesions and gene expression profiling. Here we show that expression of the MET oncogene, encoding the tyrosin...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36426 | biostudies-arrayexpress
TranscriptomicsMulcom: a multiple comparison statistical test for microarray data in Bioconductor (Illumina)
Background Many microarray experiments search for genes with differential expression between a common “reference” group and multiple test groups, like in the case of time-course designs or of various treatments versus a control condition. In such cases, currently employed statistical approaches base...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-26735 | biostudies-arrayexpress
TranscriptomicsMulcom: a multiple comparison statistical test for microarray data in Bioconductor (Affymetrix)
Background Many microarray experiments search for genes with differential expression between a common “reference” group and multiple test groups, like in the case of time-course designs or of various treatments versus a control condition. In such cases, currently employed statistical approaches base...
ORGANISM(S): Homo sapiens 
2011-08-09 | E-GEOD-26732 | biostudies-arrayexpress
TranscriptomicsCancer stem cells from lobular infiltrating breast tumor metastasize to bone and acquire a gene signature associated to bone tropism
We investigated the role of breast cancer stem-like cells (CSCs-like), isolated from primary tumor, in promoting bone metastases in a human-in-mice model. Luciferase-transduced CD44+CD24- breast CSCs-like were injected through subcutaneous (SC) and intracardiac (IC) route in nonobese/severe combined...
ORGANISM(S): Homo sapiens 
2013-11-30 | E-GEOD-36102 | biostudies-arrayexpress
TranscriptomicsIdentification of p130Cas/ErbB2-dependent invasive signatures in transformed mammary epithelial cells
Understanding transcriptional changes during cancer progression is of crucial importance to develop new and more efficacious diagnostic and therapeutic approaches. It is well known that ErbB2 is overexpressed in about 25% of human invasive breast cancers. We have previously demonstrated that p130Cas...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-42949 | biostudies-arrayexpress
TranscriptomicsHepatocytes obtained from mouse GPSCs are functional and show similar expression profiles to fetal primary hepatocytes
Germline cell-derived pluripotent stem cells (GPSCs) are similar to embryonic stem (ES) cells in that they can proliferate intensively and differentiate into a variety of cell types, including cardiomyocytes and neurons. In this report, mouse GPSCs were induced to differentiate into hepatocytes with...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-19044 | biostudies-arrayexpress
TranscriptomicsStromal contribution to expression signatures of colorectal cancer (rectal samples)
We noticed that a recently identified poor prognosis stem/serrated molecular subtype of colorectal cancer (CRC) is characterized by up-regulation of transcripts known to be also expressed by stromal cells. To better define the origin of such transcripts, we analyzed RNAseq and microarray datasets f...
ORGANISM(S): Homo sapiens 
2014-05-01 | E-GEOD-56699 | biostudies-arrayexpress
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