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TranscriptomicsExpression data from pooled biological replicates (n=6) from MEF2D knockdown in neonatal rat ventricular myocytes (NRVMs)
Differentiation and maintenance of cardiac muscle is a complex biological process. MEF2D appears to play an important role in the regulation of cardiomyocyte homeostasis. We knocked down expression of MEF2D in NRVMs, and assessed global expression pattern changes in MEF2D knockdown against a negativ...
ORGANISM(S): Rattus norvegicus 
2015-08-31 | E-GEOD-72157 | biostudies-arrayexpress
ProteomicsMEF2A, MEF2C, and MEF2D Interactomes in Mouse MA-10 Leydig Cells
In steroidogenic Leydig cells, MEF2A, MEF2C, and MEF2D are key regulators of genes involved in steroid hormone synthesis, reproductive function, and oxidative stress defense. Here we used TurboID proximity-mediated biotinylation to map the protein-protein interaction networks of MEF2A, MEF2C, and ME...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-11-15 | MSV000096432 | MassIVE
Proteomicsp38γ and p38δ modulate innate immune response by regulating MEF2D activation
Evidence implicating p38γ and p38δ (p38γ/p38δ) in inflammation are mainly based on experiments using p38γ/p38δ deficient (p38γ/δ-/-) mice, which show low levels of TPL2, the kinase upstream of MKK1-ERK1/2 in myeloid cells. This could obscure p38γ/p38δ roles, since TPL2 is essential for regulating in...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-10 | PXD042626 | Pride
Inflammation Mef2d P38δ Phosphorylation P38γ 
TranscriptomicsRNA-Seq profiling of C2C12 cells with exogenous expression of Mef2Da1 and Mef2Da2
Although splicing occurs in most multi-exon genes, the generation of distinct isoforms through the alternate use of mutually exclusive exons is less prevalent. As exon-switching events have the potential to give rise to isoforms with different cellular functions, we have explored the role of the mus...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-46363 | biostudies-arrayexpress
TranscriptomicsRNA-seq for gene expression changes upon silencing MEF2D-fusion in a MEF2D-HNRNPUL1 fusion-expressing Kasumi-7 cell line
To explore the mechanisms underlying the maintenance of acute lymphoblastic leukemia harboring fusion genes involving MEF2D transcription factor, the MEF2D-fusion was silenced by shRNA and the resulting gene expression changes were analyzed by RNA-seq.
ORGANISM(S): Homo sapiens 
2020-06-30 | E-MTAB-8480 | biostudies-arrayexpress
GenomicsRNA-seq for gene expression changes upon silencing MEF2D-fusion in a MEF2D-HNRNPUL1 fusion-expressing Kasumi-7 cell line
RNA-seq for gene expression changes upon silencing MEF2D-fusion in a MEF2D-HNRNPUL1 fusion-expressing Kasumi-7 cell line
PRJEB35113 | ENA
GenomicsMEF2D functions as a tumor suppressor in breast cancer
MEF2D functions as a tumor suppressor in breast cancer
PRJNA1109388 | ENA
GenomicsGenomic Analyses Identify Recurrent MEF2D Fusions in Acute Lymphoblastic Leukemia
Chromosomal rearrangements are initiating events in acute lymphoblastic leukemia (ALL). Here, using RNA-sequencing (RNAseq) of 560 ALL cases, we identify rearrangements between MEF2D (myocyte enhancer factor 2D) and five genes (BCL9, CSF1R, DAZAP1, HNRNPUL1 and SS18) in 22 B progenitor ALL (B-ALL) c...
EGAS00001001952 | EGA
GenomicsMEF2D-HNRNPUL1 ChIP-seq in a genome-edited Kasumi-7 cell line
MEF2D-HNRNPUL1 ChIP-seq in a genome-edited Kasumi-7 cell line
PRJEB35064 | ENA
TranscriptomicsGene expression signatures of MEF2D-silencing hepatocellular carcinoma cells
Global expression profiles in Huh7 after infection with Lv-shMEF2D and Lv-scrambled, as well as transfection with siRNA-MEF2D and siRNA-control, were compared to investigate the molecular mechanisms involved in MEF2D-mediated regulation of cell cycle. In order to investigate the molecular mechanisms...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-37123 | biostudies-arrayexpress
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