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ProteomicsSystematic analysis of synergistic proteome modulations in a drug combination of cisplatin and MLN4924
Chemotherapeutic treatment regimens often take advantage of synergistic effects of drug combinations. Anticipating that synergistic effects on cell biological level likely manifest on proteome level, the analysis of proteome modulations represents an appropriate strategy to study drug combinations o...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD009185 | Pride
Human Synergy Lc-ms/ms 
ProteomicsDeciphering of the human interferome and its kinetics of protein induction and repression by mass spectrometry-based quantitative proteome analysis
Interferons (IFNs) are pleotropic cytokines secreted upon encounter of pathogens and tumors. Applying their antipathogenic, antiproliferative and immune stimulatory capacities, recombinant IFNs are frequently prescribed as drugs to treat different diseases. IFNs act by changing the transcription of ...
ORGANISM(S): Homo sapiens (Human) 
2018-05-25 | PXD006442 | Pride
Interferome Interferon gamma Label-free quantification Interferon alpha 
ProteomicsLabel-free Proteomic Analysis of Exosomes Secreted from THP-1-Derived Macrophages in the Absence or Presence of Interferon-α
Exosomes are extracellular vesicles that function in intercellular communication. We have previously reported that exosomes play a role in the transmission of antiviral molecules during interferon-α (IFN-α)-mediated immune responses. In this study, the protein contents of THP-1-derived macrophages w...
ORGANISM(S): Homo sapiens (Human) 
2018-12-17 | PXD009746 | Pride
Ifn-α  exosomes  macrophages  label-free quantification  isgs 
ProteomicsHuman Bile LC-MS/MS - One Sample, One Shot - Evaluation of sample preparation protocols for the mass spectrometric proteome analysis of human bile fluid without extensive fractionation
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would...
ORGANISM(S): Homo sapiens (Human) 
2017-05-03 | PXD004476 | Pride
Method comparison Proteomics Hepatocellular carcinoma Bile fluid Biomarkers Cholangiocellular carcinoma 
ProteomicsStructurally related hydrazone-based metal complexes with different antitumor activities variably induce apoptotic cell death
Three new complexes bearing the tridentate hydrazone-based ligand 2-(2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)pyridine (L) were synthesized and structurally characterized. Biological tests indicate that the Zn(II) complex [ZnCl2(L)] • 0.5 H2O is of low cytotoxicity against the hepatocellular carcino...
ORGANISM(S): Homo sapiens (Human) 
2017-05-03 | PXD005507 | Pride
Lc-ms/ms Metal complexes Liver cancer 
ProteomicsHuman Bile LC-MS/MS
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082926 | MassIVE
ProteomicsA comparative analysis of the interactomes of viral accessory proteins exploiting DDB1 and Cullin Ubiquitin ligases
Viruses have an ambivalent relationship with the host proteome. While several host proteins are indispensable for replication, detrimental restriction factors need to be antagonized. This process is frequently catalysed by viral accessory proteins which exploit the ubiquitin proteasome pathway, DDB1...
ORGANISM(S): Homo sapiens (Human) 
2019-01-14 | PXD007634 | Pride
Proteomics Mass spectrometry Cullin ubiquitin ligases Ddb1 Viral interactome analysis 
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