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TranscriptomicsIntegrated genomic and transcriptional profiling yields putative marker genes for cervical cancer
A better understanding of the consequences of recurrent (epi)genetic alterations that occur during cervical carcinogenesis is essential in the search for novel biomarkers. In this study we determined genome-wide expression profiles of 10 squamous cell carcinomas (SCCs), 5 adenocarcinomas (AdCAs) and...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-6473 | biostudies-arrayexpress
TranscriptomicsGastric cancers of Western European and African patients
Gastric cancer is the second most common cause of cancer death worldwide, but incidence and mortality rates show large variations across different countries. Variation in risk factors between different populations, including environmental and host factors influencing gastric cancer risk, have been r...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-22789 | biostudies-arrayexpress
TranscriptomicsLosses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome
Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-26389 | biostudies-arrayexpress
TranscriptomicsSmall bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers
Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chr...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-23418 | biostudies-arrayexpress
TranscriptomicsChromosomal copy number aberrations in colorectal metastases resemble their primary counterparts and differences are typically non-recurrent.
Background & Aims: The metastatic process is complex and remains a major obstacle in the management of colorectal cancer (CRC). To gain a better insight into the biologic events driving the metastatic process we investigated genomic aberrations in a large cohort of matched CRC primaries and distant ...
ORGANISM(S): Homo sapiens 
2014-02-10 | E-GEOD-38479 | biostudies-arrayexpress
TranscriptomicsIdentification of markers associated with deregulated hTERT during HPV-medaited transformation
Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit hTERT. Our previo...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8288 | biostudies-arrayexpress
TranscriptomicsImmortalization capacity of HPV types is inversely related to chromosomal instability in immortal descendants.
Human papillomavirus (HPV) induced immortalization of human foreskin keratinocytes (HFK) is a two-step process, including 1) the bypass of replicative senescence and acquisition of an extended lifespan, and 2) the outgrowth of immortal cells. Our previous study showed that the immortalization capaci...
ORGANISM(S): Homo sapiens 
2016-08-01 | E-GEOD-72063 | biostudies-arrayexpress
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
UnknownLongitudinal study of hippocampal volumes in heavy cannabis users.
Not available
S-EPMC5544121 | biostudies-literature
UnknownTargeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis.
Not available
S-EPMC6428681 | biostudies-literature
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