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TranscriptomicsLosses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome
Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-26389 | biostudies-arrayexpress
TranscriptomicsGastric cancers of Western European and African patients
Gastric cancer is the second most common cause of cancer death worldwide, but incidence and mortality rates show large variations across different countries. Variation in risk factors between different populations, including environmental and host factors influencing gastric cancer risk, have been r...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-22789 | biostudies-arrayexpress
TranscriptomicsDeletion of chromosome 4q predicts outcome in Stage II colon cancer
Background: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters for identification of high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, are established. With traditional histopathological feat...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-17181 | biostudies-arrayexpress
TranscriptomicsCandidate driver genes in focal chromosomal aberrations of stage II colon cancer
Chromosomal instable colorectal cancer is marked by specific large chromosomal copy number aberrations. Recently, focal aberrations of 3Mb or smaller have been identified as a common phenomenon in cancer. Inherent to their limited size, these aberrations harbour one or few genes. The aim of this stu...
ORGANISM(S): Homo sapiens 
2010-04-19 | E-GEOD-17047 | biostudies-arrayexpress
TranscriptomicsMultiple genes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression
Chromosomal instability (CIN) is the hallmark of colorectal adenoma to carcinoma progression in 85% of cases, with 20q gain as the most prominent aberration. Yet, the oncogenes at this chromosomal gain are still largely unknown. Here, we aimed to identify oncogenes at 20q involved in colorectal aden...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-8067 | biostudies-arrayexpress
TranscriptomicsSmall bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers
Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chr...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-23418 | biostudies-arrayexpress
TranscriptomicsThree commercial array platforms compared for DNA copy number detection with DNA isolated from FFPE tissue [NimbleGen]
Formalin-fixed, paraffin-embedded (FFPE) archival tissue is an important source of DNA material. The most commonly used technique to identify copy number aberrations from chromosomal DNA in tumorigenesis is array comparative genomic hybridization (aCGH). Although copy number analysis using DNA from ...
ORGANISM(S): Homo sapiens 
2012-01-17 | E-GEOD-30120 | biostudies-arrayexpress
TranscriptomicsTen percent of aberrant cells is sufficient for detection of DNA copy number alterations (part 1)
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. The aim of our present study is to evaluate to what extent aCGH can detect DNA copy number alterat...
ORGANISM(S): Homo sapiens 
2012-10-21 | E-GEOD-36856 | biostudies-arrayexpress
TranscriptomicsTen percent of aberrant cells is sufficient for detection of DNA copy number alterations (part 5)
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. The aim of our present study is to evaluate to what extent aCGH can detect DNA copy number alterat...
ORGANISM(S): Homo sapiens 
2012-10-21 | E-GEOD-36992 | biostudies-arrayexpress
TranscriptomicsTen percent of aberrant cells is sufficient for detection of DNA copy number alterations (part 3)
Array Comparative Genomic Hybridization (aCGH) is a widely used technique to assess chromosomal copy number alterations. Chromosomal content, however, is often not uniform throughout cell populations. The aim of our present study is to evaluate to what extent aCGH can detect DNA copy number alterat...
ORGANISM(S): Homo sapiens 
2012-10-21 | E-GEOD-36989 | biostudies-arrayexpress
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