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TranscriptomicsSpecificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection
Pathogenic mycobacteria have the ability to survive within macrophages and persist inside granulomas composed of host immune cells. The complex host-pathogen interactions that determine the outcome of a mycobacterial infection process result in marked alterations of the host gene expression profile....
ORGANISM(S): Danio rerio 
2010-05-15 | E-GEOD-15328 | biostudies-arrayexpress
MetabolomicsRegulatory T cells promote endurance exercise adaptation by shielding muscle mitochondria from damage

Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. While some effector mechanisms have been identified, regul...

2023-10-10 | MTBLS8391 | MetaboLights
TranscriptomicsSalmonella typhimurium infection of zebrafish embryo
Characterization of the zebrafish embryonic host response to systemic bacterial infection with Salmonella typhimurium wild type strain (SL1027) and its isogenic LPS O-antigen mutant Ra (SF1592) by means of a time-resolved global expression analysis. All infection experiments were performed using mix...
ORGANISM(S): Danio rerio 
2010-05-22 | E-GEOD-13994 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection
Salmonella enterica serovar Typhimurium (S. typhimurium) bacteria cause an inflammatory and lethal infection in zebrafish embryos. To characterize the embryonic innate host response at the transcriptome level, we have extended and validated previous microarray data by Illumina next-generation sequen...
ORGANISM(S): Danio rerio 
2010-10-25 | E-GEOD-22472 | biostudies-arrayexpress
TranscriptomicsJeB001: Elucidation of the distal convoluted tubule transcriptome identified new candidate players in magnesium balance
The distal convoluted tubule (DCT) plays a key role in the fine-tuning of renal Mg2+ reabsorption. In recent years, hereditary magnesium (Mg2+) transport disorders have helped to identify important players in DCT Mg2+ homeostasis. Here, we report the Mg2+-sensitive transcriptional expression of the ...
ORGANISM(S): Mus musculus 
2013-12-13 | E-GEOD-40208 | biostudies-arrayexpress
TranscriptomicsTraf6 function in the innate immune response of zebrafish embryos
Transcriptional profiling of the zebrafish embryonic host response to a systemic bacterial infection with Salmonella typhimurium (strain SL1027); comparison between traf6 knock-down and control morpholino treated embryos. Two-way factorial dual colour design with factor 1 'infection with Salmonella ...
ORGANISM(S): Danio rerio 
2010-08-01 | E-GEOD-20310 | biostudies-arrayexpress
TranscriptomicsDeficiency in hematopoietic phosphatase Ptpn6/Shp1 hyperactivates the innate immune system and impairs control of bacterial infections in zebrafish embryos
Deficiency in the protein-tyrosine phosphatase SHP1/PTPN6 is linked with hematological malignancies and chronic inflammatory diseases. Here we exploited the embryonic and larval stages of zebrafish as an animal model to study ptpn6 function in the sole context of innate immunity. We show that ptpn6 ...
ORGANISM(S): Danio rerio 
2012-12-31 | E-GEOD-34930 | biostudies-arrayexpress
TranscriptomicsTranscriptomic approaches in the zebrafish model for tuberculosis – insights into host- and pathogen-specific determinants of the innate immune response
Both embryonic and adult zebrafish Mycobacterium marinum infection studies have contributed to our knowledge of the development and function of tuberculous granulomas, which are typical for mycobacterial pathogenesis. In this review we discuss how transcriptome profiling studies have helped to chara...
ORGANISM(S): Danio rerio 
2016-06-01 | E-GEOD-76499 | biostudies-arrayexpress
TranscriptomicsMacrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish
Macrophage expressed gene 1 (MPEG1) encodes an evolutionary conserved protein with a predicted Membrane Attack Complex/Perforin domain associated with host defence against invading pathogens. In vertebrates, MPEG1 is an integral membrane protein of macrophages, but how it contributes to the macropha...
ORGANISM(S): Danio rerio 
2014-09-01 | E-GEOD-54885 | biostudies-arrayexpress
TranscriptomicsMarker gene discovery for Staphylococcus epidermidis infection in zebrafish embryos (Agilent)
We use the zebrafish embryo model to study the innate immune response against Staphylococcus epidermidis. Therefore, we injected S. epidermidis (and three controls groups) into the yolk at 2 hpf and samples at mutiple timepoints. Gene expression profiles were obtained at 6, 30, 54, 78, 102 and 126 h...
ORGANISM(S): Danio rerio 
2013-04-01 | E-GEOD-37227 | biostudies-arrayexpress
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