Sort   by:  
 Page size 
GenomicsGenome-wide DNA methylation maps in chronic lymphocytic leukemia cells determined by next-generation sequencing
We conducted a genome-wide DNA methylation analysis in CD19+ B-cells from CLL patient and normal control samples using reduced representation bisulfite sequencing (RRBS). The methylation status of 1.8-2.3 million CpGs in the CLL genome was determined; about 45% of these CpGs were located in more tha...
ORGANISM(S): Homo sapiens 
2012-05-10 | E-GEOD-32698 | biostudies-arrayexpress
GenomicsBLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
EGAS00001001598 | EGA
GenomicsWidespread targeted chromatin remodeling during the initial phase of somatic cell reprogramming [RRBS]
Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem (iPS) cell state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcri...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-26098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse differentiated, partially- and fully-reprogrammed MEFs/B-cells
Expression profiles generated during dissection of the molecular mechanisms underlying direct reprogramming of somatic cells to a pluripotent state (induced pluripotent stem cells, iPS). Experiment Overall Design: 2 technical replicates of B lymphocytes, partially reprogrammed (MCV8, MCV6, BIV1), M...
ORGANISM(S): Mus musculus 
2008-06-18 | E-GEOD-10871 | biostudies-arrayexpress
GenomicsGenome-scale DNA methylation maps of pluripotent and differentiated cells
We report the generation and analysis of genome-scale DNA methylation profiles at nucleotide resolution in mammalian cells. Using high-throughput Reduced Representation Bisulfite Sequencing (RRBS) and single-molecule-based sequencing, we generated DNA methylation maps covering the vast majority of C...
ORGANISM(S): Mus musculus 
2008-07-06 | E-GEOD-11034 | biostudies-arrayexpress
ProteomicsC9ORF72 interaction with cofilin modulates actin dynamics in motoneurons
Intronic hexanucleotide expansions in C9ORF72 are common in ALS and FTLD, but it is unknown whether loss of function, toxicity by the expanded RNA or dipeptides from non ATG-initiated translation are responsible for the pathophysiology. We determined the interactome of C9ORF72 in motoneurons and fou...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-30 | PXD004913 | Pride
Ftld Cofilin Als C9orf72 
UnknownA Novel (18)F-Labeled Imidazo[2,1-b]benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques.
Not available
S-EPMC4018122 | biostudies-literature
UnknownPDGF-B Is Required for Development of the Glymphatic System.
Not available
S-EPMC6447074 | biostudies-literature
UnknownThe double-hit signature identifies double-hit diffuse large B-cell lymphoma with genetic events cryptic to FISH.
Not available
S-EPMC6839951 | biostudies-literature
TranscriptomicsNLRC5 is a transcriptional regulator of MHC class I genes
NLRC5 is a member of the NLR family of proteins. The observation that NLRC5 is found in the nucleus prompted us to perform a gene array to identify putative target genes of NLRC5. We generated Jurkat T cell lines that stably express either the wild-type or mutant forms of NLRC5 harboring mutations i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22064 | biostudies-arrayexpress
Sort   by:  
 Page size