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GenomicsWidespread targeted chromatin remodeling during the initial phase of somatic cell reprogramming [RRBS]
Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem (iPS) cell state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcri...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-26098 | biostudies-arrayexpress
GenomicsGenome-scale DNA methylation maps of pluripotent and differentiated cells
We report the generation and analysis of genome-scale DNA methylation profiles at nucleotide resolution in mammalian cells. Using high-throughput Reduced Representation Bisulfite Sequencing (RRBS) and single-molecule-based sequencing, we generated DNA methylation maps covering the vast majority of C...
ORGANISM(S): Mus musculus 
2008-07-06 | E-GEOD-11034 | biostudies-arrayexpress
GenomicsGenome-wide chromatin state maps of ES cells, ES-derived neural progenitor cells and brain tissue
Genome-wide chromatin state maps of murine embryonic stem (ES) cells, ES-derived neural progenitor cells and whole brain tissue. The data were generated to examine the correlation between histone and DNA methylation during lineage-commitment. Keywords: High-throughput ChIP-sequencing, Illumina, cell...
ORGANISM(S): Mus musculus 
2008-07-05 | E-GEOD-11172 | biostudies-arrayexpress
GenomicsGenomic distribution and inter-sample variation of non-CG methylation across human cell types
DNA methylation plays an important role in development and disease. The primary sites of DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account for roughly three quarters of the total DNA methylation content in human and mouse cells. While the genomic distributio...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-27432 | biostudies-arrayexpress
Unknown(1)H NMR-based metabolic profiling of urinary tract infection: combining multiple statistical models and clinical data.
Not available
S-EPMC3483096 | biostudies-literature
UnknownGenome comparison between clinical and environmental strains of Herbaspirillum seropedicae reveals a potential new emerging bacterium adapted to human hosts.
Not available
S-EPMC6679464 | biostudies-literature
UnknownChannel Gating Dependence on Pore Lining Helix Glycine Residues in Skeletal Muscle Ryanodine Receptor.
Not available
S-EPMC4498087 | biostudies-literature
ProteomicsA mass spectrometry guided pre-clinical funnel for the identification of novel vaccine candidates against Helicobacter pylori
We established a generic pipeline for the identification of surface-exposed vaccine candidates in gram-negative bacteria. Using Helicobacter pylori as a model organism, our approach combines design of experiment driven surface shaving with quantitative mass spectrometry to identify 22 highly conserv...
ORGANISM(S): Helicobacter pylori J99 (Campylobacter pylori J99) 
2019-11-11 | PXD012566 | Pride
Proteomics Vaccine Surfome Helicobacter pylori 
UnknownHELLS is required for maintaining proper DNA modification at human satellite repeats.
Not available
S-EPMC12273238 | biostudies-literature
ProteomicsTDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons
Whole proteome quantification identified upregulation of the ESCRT component VPS4B upon TDP-43 knockdown in neurons.
ORGANISM(S): Rattus norvegicus (Rat) 
2016-09-29 | PXD004756 | Pride
Ftld Recycling endosomes Tdp-43 Als Erbb4 
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