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ProteomicsIntracellular pH regulates the ubiquitin-mediated degradation of the atypical MAP kinase ERK3
The atypical mitogen-activated protein kinase ERK3 is known for its instability and degradation via the ubiquitin-proteasome system (UPS). However, the specific environmental factors regulating ERK3 turnover have remained unclear. In this study, we demonstrate that intracellular pH (pHi) plays a cru...
ORGANISM(S): Homo sapiens (Human) 
2025-10-07 | PXD056239 | Pride
Map kinases  erk3  ph  protein stability 
ProteomicsPhosphoproteomic analysis identifies supervillin as a new ERK3 substrate regulating cytokinesis and ploidy of breast cancer cells
Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used ...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD028061 | Pride
Breast cancer Cytokinesis Supervillin Erk3 Ploidy Phosphoprotoemic 
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