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ProteomicsMeltome Atlas - thermal proteome stability across the tree of life
We have developed a mass spectrometry-based approach that allowed us to quantitatively monitor protein stability across a broad range of temperatures at the proteome scale (meltome). We profiled the meltomes of several microorganisms and eukaryotic species including human, allowing to investigate th...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Picrophilus torridus Oleispira antarctica Arabidopsis thaliana (Mouse-ear cress) Mus musculus (Mouse) Drosophila melanogaster (Fruit fly) Caenorhabditis elegans Geobacillus stearothermophilus Homo sapiens (Human) Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) Bacillus subtilis 
2020-04-29 | PXD011929 | Pride
Protein stability Thermostability Meltome atlas Melting point Thermal proteome profiling 
UnknownThermal Proteome Profiling Reveals the O-GlcNAc-Dependent Meltome.
Not available
S-EPMC8969899 | biostudies-literature
ProteomicsThermal proteome profiling in Escherichia coli
We adapted thermal proteome profiling (TPP) to study the thermostability of Escherichia coli proteins in vivo. We monitored the E. coli meltome and proteome at different growth phases, in a tolC knock-out mutant and after drug treatment.
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2018-07-09 | PXD009495 | Pride
Target engagement Escherichia coli Drugs Growth phase Meltome Thermal proteome profiling 
ProteomicsThermal proteome profiling reveals meltome upon NLRP3 inflammasome activation
NLR family pyrin domain containing 3 (NLRP3) involves in inflammasome complex assembly and innate immunity. Activation of the NLRP3 inflammasome induces conformational alterations in protein complexes, influencing their interactions with other molecules, which in turn affects protein thermal stabili...
ORGANISM(S): Mus Musculus 
PXD063269 |
UnknownGPMelt: A hierarchical Gaussian process framework to explore the dark meltome of thermal proteome profiling experiments.
Not available
S-EPMC11463780 | biostudies-literature
UnknownMeltome Atlas of Arabidopsis thaliana proteome: a melting temperature-based identification of heat and cold resistant proteins using in-silico approach.
Not available
S-EPMC12664233 | biostudies-literature
ProteomicsMeltome Analysis of Geobacillus thermoleoverans ARTRW1
Thermal Proteome Profiling (TPP) analysis has been applied to a thermophilic bacterial proteome, recently isolated strain of Geobacillus thermoloverans, ARTW1 and thermal stability of more than 1000 proteins were presented. The thermal proteome was investigated in terms of thermostable enzymes that ...
ORGANISM(S): Geobacillus thermoleovorans 
2020-10-14 | PXD018380 | Pride
Tmt Tpp Proteome Thermal proteome profiling 
ProteomicsMeltome of P. falciparum across intraerythrocytic developmental cycle
Intact cell cellular thermal shift assay (CETSA) was performed on P. falciparum parasites and quantified by mass spectrometry. The experiment was performed in 7 blood stage timepoints (4, 10, 16, 22, 28, 34, 40 hpi) of a continuous parasite culture and repeated three times.
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum (isolate 3D7) 
2025-08-31 | PXD056075 | Pride
Malaria Falciparum Blood Plasmodium 
UnknownThermal proteome profiling in bacteria: probing protein state in vivo.
Not available
S-EPMC6056769 | biostudies-literature
ProteomicsArylsulfamates inhibit colonic Bacteroides growth through lipid kinases and not sulfatases
Excessive degradation of the colonic mucin layer by Bacteroides within the human gut microbiota drives inflammatory bowel disease in mice. Bacterial carbohydrate sulfatases are key enzymes in gut colonization, as they are elevated in human inflammatory bowel disease and correlate with disease severi...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Bacteria 
2025-07-28 | PXD065411 | Pride
Sulfatase Bacteroides thetaiotaomicron Thermal proteome profiling Arylsulfamate 
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