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MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
MetabolomicsWalnut protein hydrolysate alleviates neuroinflammation and memory impairment in naturally aged mice via a gut microbiota-metabolite-neuroinflammation axis
This study investigated age-associated alterations in the serum metabolome and the metabolic effects of walnut protein hydrolysate (WPH) supplementation in naturally aged mice. Male C57BL/6J mice at different ages (2-month, 10-month and 18-month) were used to characterize metabolic changes associate...
2026-09-04 | MTBLS15363 | MetaboLights
MetabolomicsCD22 Blockade Alleviates Anesthesia Surgery-Mediated Cognitive Impairment in Aged Mice

Postoperative cognitive dysfunction (POCD) is a common complication characterized by cognitive decline following surgery, with neuroinflammation serving as a critical pathogenic mechanism. Emerging evidence indicates that CD22, an inhibitory receptor primarily expressed on B cells and microglia, ...

2025-09-24 | MTBLS13028 | MetaboLights
TranscriptomicsTranscriptional profile of mice with good and poor spatial learning during West Nile virus recovery
Greater than 50% of patients who survive neuroinvasive West Nile virus (WNV), a mosquito-borne, positive-sense strand flavivirus, exhibit cognitive sequelae including memory impairments which may last several years. High survival rates from WNV neuroinvasive disease (WNND) (>90%) have led to hundred...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-72139 | biostudies-arrayexpress
TranscriptomicsAltered gene expression is associated with age-dependent memory impairment
The mechanisms underlying age-associated memory impairment are not well understood. We have shown that the onset of memory disturbances in the aging brain is associated with altered hippocampal chromatin plasticity. During learning, aged mice display a specific deregulation of histone H4 lysine 12...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-20270 | biostudies-arrayexpress
TranscriptomicsConditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration
ATP6AP2 is an essential accessory component of the vacuolar H+ ATPase (V-ATPase) and has been associated with intellectual disabilities (ID) and Parkinsonism. ATP6AP2 has been implicated in several signaling pathways, but little is known about its role in the nervous system. To decipher its function...
ORGANISM(S): Mus musculus 
2015-09-22 | E-GEOD-67541 | biostudies-arrayexpress
GenomicsDifferential expression contributing to memory impairment in AD context
Differential expression contributing to memory impairment in AD context
PRJNA614553 | ENA
UnknownPositivity effect specific to older adults with subclinical memory impairment.
Not available
S-EPMC4947236 | biostudies-literature
GenomicsEndogenous retroviruses are associated with hippocampus-based memory impairment
Endogenous retroviruses are associated with hippocampus-based memory impairment
PRJNA573055 | ENA
TranscriptomicsHippocampal gene expression in aged and young HSD1 knockout mice
Mice deficient in the glucocorticoid-regenerating enzyme 11β-HSD1 resist age-related spatial memory impairment. To investigate the mechanisms/pathways involved, we used microarrays to identify differentially expressed hippocampal genes that associate with cognitive ageing and 11β-HSD1. Aged wild-t...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-68515 | biostudies-arrayexpress
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