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ProteomicsIdentification of ASC-interacting proteins
To explore the spatiotemporal regulation of ASC speck formation and inflammasome activation, we infected primary WT and Asc–/– bone marrow-derived macrophages (BMDMs) with the bacterium Francisella novicida to induce AIM2 inflammasome activation and then performed ASC IP-MS to identify proteins that...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-29 | PXD052497 | Pride
Asc Francisella novicida Inflammasome Bmdm Mouse 
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
UnknownZe-qi Decoction Inhibits Neutrophil Extracellular Trap Formation to Suppress the Progression and Metastasis of Non-Small Cell Lung Cancer
Not available
S-EPMC12909755 | biostudies-literature
UnknownThe Role of Probiotics in Managing Glucose Homeostasis in Adults with Prediabetes: A Systematic Review and Meta-Analysis.
Not available
S-EPMC10963111 | biostudies-literature
UnknownNo genetic causal relationship between acne and prostate cancer through Mendelian randomization combined with meta-analysis.
Not available
S-EPMC11446721 | biostudies-literature
Proteomicsiotin-streptavidin affinity purification mass spectrometry of proteins in human 293T cell using bioinylated Orf9b
COVID-19, caused by the new RNA virus strain SARS-CoV-2, is a serious acute respiratory disease. One of the prominent feature of SARS-COV-2 in terms of immune responses is that it triggers very low level responses of IFN-I in cells or COVID-19 patients. Previously SARS-CoV Orf9b were reported to be ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019803 | Pride
Ap-ms Human 293t cell Silac Sars-cov-2 orf9b 
UnknownAnalysis of the impact of underlying diseases in the elderly on postoperative re-fractures after osteoporotic compression fractures.
Not available
S-EPMC11389243 | biostudies-literature
UnknownFXR1 is a novel MRE11-binding partner and participates in oxidative stress responses.
Not available
S-EPMC7299265 | biostudies-literature
MetabolomicsPrimary Osteocyte Supernatants Metabolomic Profiling of Two Transgenic Mice with Connexin43 Dominant Negative Mutants

Osteocytes could release some small molecules (≤ 1 kDa) through gap junctions and hemichannels to extracellular environment, such as prostaglandin E2 (PGE2), nitric oxide (NO) and adenosine triphosphate (ATP), which play key roles in transferring signals between bone cells and other tissue cells....

2021-04-14 | MTBLS2358 | MetaboLights
UnknownConstruction of synthetic anti-fouling consortia: fouling control effects and polysaccharide degradation mechanisms.
Not available
S-EPMC10631183 | biostudies-literature
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