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TranscriptomicsAlterations in the gene expression profile in SKOV3 cells exposed to elaiophylin
Elaiophylin was screened and identified as a novel autophagy inhibitor, with significant antitumor efficacy as a single agent. To explore the mechanisms by which elaiophylin kills cancer cells, NimbleGen 12x135K microarrays were used to find the gene expression changes in SKOV3 cells treated with el...
ORGANISM(S): Homo sapiens 
2022-06-07 | GSE205529 | GEO
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
TranscriptomicsTracing the transcriptomic changes of synthetic trigenomic allohexaploid in Brassica by RNA-Seq approach
We explored the transcriptomic changes of synthetic Brassica allohexaploid by comparing to its parents using a high-throughput RNA-Seq method. A total of 35644409 sequence reads were generated, and 32642 genes were aligned from the data. There were 29260, 29060 and 29697 genes identified in Brassica...
ORGANISM(S): Brassica carinata x Brassica rapa 
2014-10-10 | E-GEOD-46299 | biostudies-arrayexpress
MetabolomicsFlavonoid Biosynthesis Is Likely More Susceptible to Elevation and Tree Age Than Other Branch Pathways Involved in Phenylpropanoid Biosynthesis in Ginkgo Leaves
Ginkgo leaves are always resources for flavonoids pharmaceutical industry. However, the effect of the elevation and tree age changes on flavonoid biosynthesis have not been detailly explored in Ginkgo leaves. In addition, whether these environmental pressures have similar effects on the biosynthesis...
2020-12-14 | MTBLS962 | MetaboLights
ProteomicsProtein phosphorylation networks in Baylisascaris procyonis revealed by phosphoproteomic analysis
Background: Baylisascaris procyonis is an intestinal ascarid worm that parasitizes in raccoons and causes fatal neural, visceral, and ocular larva migrans in humans. Phosphorylated proteins and protein kinases have been studied as vaccine and drug target candidates against parasitic infections. Howe...
ORGANISM(S): Baylisascaris procyonis 
2025-08-04 | PXD066529 | Pride
Raccoon Liquid chromatography-mass spectrometry Signaling pathway Baylisascaris procyonis Phosphoproteome Function 
ProteomicsAnalysis of the protein corona on nanoparticles in mouse plasma
We designed three types of nanoparticles with different lipid compositions, each exhibiting distinct tumor accumulation efficiencies. By isolating the protein corona formed on these nanoparticles in mouse plasma, we performed mass spectrometry to characterize the differential protein adsorption prof...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD063915 | Pride
Protein corona Nanoparticle 
GenomicsAlterations in the gene expression profile in SKOV3 cells exposed to elaiophylin
Alterations in the gene expression profile in SKOV3 cells exposed to elaiophylin
PRJNA846276 | ENA
ProteomicsThe ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme that catalyzes all O-GlcNAcylation reactions intracellularly. Previous investigations have found that OGT levels oscillate during the cell division process. Specifically, OGT abundance is downregulated during mitosis, but...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050552 | Pride
Uterine carcinoma Ubiquitination Cell cycle Ogt Apc/ccdc20 
UnknownResveratrol alleviates oxidative stress induced by oxidized soybean oil and improves gut function via changing gut microbiota in weaned piglets.
Not available
S-EPMC10080898 | biostudies-literature
UnknownProtein tyrosine phosphatase receptor type D (PTPRD)-mediated signaling pathways for the potential treatment of hepatocellular carcinoma: a narrative review.
Not available
S-EPMC7576031 | biostudies-literature
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