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ProteomicsThe ubiquitin E3 ligase APC/CCdc20 mediates mitotic degradation of OGT
O-linked β-N-acetylglucosamine (O-GlcNAc) transferase (OGT) is the sole enzyme that catalyzes all O-GlcNAcylation reactions intracellularly. Previous investigations have found that OGT levels oscillate during the cell division process. Specifically, OGT abundance is downregulated during mitosis, but...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050552 | Pride
Uterine carcinoma Ubiquitination Cell cycle Ogt Apc/ccdc20 
ProteomicsAPC/CCdc20 dependent degradation of Clb4 is all there is to astral microtubule stabilization
Coordination between sister chromatid separation and segregation is crucial for accurate chromosome partitioning to the offspring. Key to this process is the ability of mitotic spindle microtubules to respond to different molecular signals and remodel their dynamics accordingly. Based on their funct...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-19 | PXD028828 | Pride
Astral microtubule stabilization 
UnknownDegradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes.
Not available
S-EPMC3243522 | biostudies-literature
ProteomicsParadoxical mitotic exit induced by a small molecule inhibitor of APC/C Cdc20
The Anaphase Promoting Complex/Cyclosome (APC/C) is a mega-dalton ubiquitin ligase that initiates mitotic exit by targeting substrates for degradation. The APC/C is activated by Cdc20, which acts as a substrate receptor, and is inhibited by the mitotic checkpoint complex (MCC), which delays mitoti...
ORGANISM(S): Homo sapiens (Human) 
2020-01-07 | PXD013786 | Pride
Cdc20 Mitosis Apcin 
UnknownMechanism of APC/CCDC20 activation by mitotic phosphorylation.
Not available
S-EPMC4868491 | biostudies-literature
UnknownMolecular mechanisms of APC/C release from spindle assembly checkpoint inhibition by APC/C SUMOylation.
Not available
S-EPMC8028313 | biostudies-literature
UnknownCalcineurin promotes APC/C activation at meiotic exit by acting on both XErp1 and Cdc20.
Not available
S-EPMC6280790 | biostudies-literature
UnknownMitotic slippage is determined by p31comet and the weakening of the spindle-assembly checkpoint.
Not available
S-EPMC7098889 | biostudies-literature
UnknownPP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20.
Not available
S-EPMC7851957 | biostudies-literature
UnknownMutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast.
Not available
S-EPMC3734102 | biostudies-literature
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