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MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsMyo19 Interacting Proteins IP-MS
This project is aimed to detect the interacting proteins of mitochondria-tageting actin motor Myo19.
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD033198 | Pride
Myo19 ip-ms 
MetabolomicsTargeting the SREBP-dependent lipidomic reprogramming by virus infection for broad-spectrum therapeutic intervention
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
MetabolomicsRectal microbiomes and serum metabolomics reveal changes in serum antioxidant status and immune responses of Dezhou donkeys in late gestation to parturition

Background: Parturition is a critical event in the reproductive cycle of dairy animals, accompanied by multiple physiological changes in sex hormones, metabolism, antioxidant capacity and immune function. However, the changes in the rectal microbiota and metabolic products of Jennies from late ge...

2025-08-27 | MTBLS12897 | MetaboLights
ProteomicsClinical characterization and proteomic profiling of lean nonalcoholic fatty liver disease
To investigate the proteomic features in lean subjects with NAFLD, and to identify possible plasma proteins that provide potential application for diagnosing of NAFLD in lean individuals. Participants with or without NAFLD were divided into an overweight NAFLD group, an overweight control group, a l...
ORGANISM(S): Homo Sapiens 
2022-07-21 | PXD035514 |
ProteomicsNoninvasive urinary protein signatures combined clinical information associated with Microvascular Invasion Risk in patients with HCC
Microvascular invasion (MVI) is the main factor affecting the prognosis of patients with hepatocellular carcinoma (HCC). There is an urgent need for reliable preoperative prediction of MVI indicators in order to formulate a reasonable treatment plan for patients.
ORGANISM(S): Homo Sapiens 
2022-10-13 | PXD037409 |
ProteomicsTo explore the binding protein of HKDC1 by IP-MS
We used Hep3B cells expressing Flag tagged HKDC1 to explore the binding protein of HKDC1 by IP-MS
ORGANISM(S): Homo Sapiens 
2023-11-29 | PXD047388 |
ProteomicsMouse Testis IP-MS Analysis of TEX44 Interacting Proteins
Through whole-exome sequencing of 800 patients with asthenozoospermia, we identified biallelic TEX44 variants in six individuals, all of whom exhibited defective mitochondrial sheath assembly and impaired sperm motility. Using Tex44 knockout mice, we demonstrated that TEX44 interacts with carnitine ...
ORGANISM(S): Mus Musculus 
2025-02-20 | PXD060989 |
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