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ProteomicsBiochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates
Crossing over between homologs is critical for the stable segregation of chromosomes during the first meiotic division. S. cerevisiae Mer3 (HFM1 in mammals) is a SF2 helicase and member of the ZMM group of proteins, that facilitates the formation of the majority of crossovers during meiosis. Here we...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-07-20 | PXD039839 | Pride
Crossover Yeast Phospho proteomics Meiosis Mer3 
GenomicsRPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis
RPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis
PRJNA1307563 | ENA
GenomicsRPA directly stimulates Mer3/HFM1 helicase processivity to ensure normal crossover formation in meiosis
Meiotic crossover formation is critical for generating viable gametes and enhancing genetic diversity. The helicase Mer3 (HFM1 in humans) is a highly conserved factor essential for promoting crossovers and ensuring their proper distribution. Here, we identify replication protein A (RPA) as a direct ...
ORGANISM(S): Saccharomyces mikatae Saccharomyces cerevisiae 
2025-11-02 | GSE305755 | GEO
UnknownBiochemical characterisation of Mer3 helicase interactions and the protection of meiotic recombination intermediates.
Not available
S-EPMC10201424 | biostudies-literature
UnknownConcerted action of the MutLβ heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion.
Not available
S-EPMC5215242 | biostudies-literature
UnknownTransposon Tagging of a Male-Sterility, Female-Sterility Gene, St8, Revealed that the Meiotic MER3 DNA Helicase Activity Is Essential for Fertility in Soybean.
Not available
S-EPMC4773125 | biostudies-literature
UnknownGenetic interactions of hypomorphic mutations in the m7G cap-binding pocket of yeast nuclear cap binding complex: an essential role for Cbc2 in meiosis via splicing of MER3 pre-mRNA.
Not available
S-EPMC3479390 | biostudies-literature
ProteomicsCross-link analysis of the Mer3-Strep + Rfa1/Rfa2/Rfa3 complex
Crosslinking mass spectrometry was performed to identify intermolecular DSBU crosslinks between a Mer3-His construct and Rfa1-3.
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2026-02-09 | MSV000100765 | MassIVE
GenomicsThe Pif1 helicase is actively inhibited during meiotic recombination to prevent excess length of gene conversions
Meiotic recombination ensures proper chromosome segregation to form viable gametes and results in gene conversion events between homologs. Conversion tracts are shorter in meiosis than in mitotically dividing cells. This results at least in part from the binding of a complex, formed of the Mer3 heli...
ORGANISM(S): Saccharomyces cerevisiae 
2021-03-01 | GSE164467 | GEO
UnknownThe Pif1 helicase is actively inhibited during meiotic recombination which restrains gene conversion tract length.
Not available
S-EPMC8096244 | biostudies-literature
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