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ProteomicsDistinct Immune Cell Functional Phenotypes in Sepsis Patients Correlates with Disease Severity
Sepsis is a highly heterogeneous syndrome that impacts immune function and response to infection. To develop targeted therapeutics, immunophenotyping is needed to identify distinct immune cell functional phenotypes. Employing organ-on-chip for neutrophil functional analysis, we identified three dist...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD041007 | Pride
Organ-on-chip Proteomics Sepsis Neutrophils Immunosupression 
ProteomicsUnraveling the Interplay of Sustained Caloric Restriction and Adipose Tissue GLUT4 Translocation in Insulin Sensitivity Regulation
Caloric restriction (CR) is a well-established dietary strategy known to enhance insulin sensitivity and mitigate the risk of metabolic disorders. Despite its proven benefits, the precise molecular mechanisms underlying CR's positive impacts remain incompletely elucidated. Therefore, the principal g...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047731 | Pride
Caloric restriction Prostacyclin synthase Tug cleavage Proteomics Insulin sensitivity 
ProteomicsProteomics of Mouse Endothelial Cell Dysfunction in Sepsis
An early aspect of sepsis is dysregulated activation of endothelial cells (EC), initiating a cascade of inflammatory signaling leading to leukocyte adhesion/migration and organ damage. Therapeutic targeting of ECs has been hampered by concerns regarding ECs heterogeneity from different organs. Using...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031804 | Pride
Inflamation Proteomics Sepsis Endothelium 
ProteomicsSecreted folate receptor-gamma drives fibrogenesis in nonalcoholic steatohepatitis by amplifying TGFβ signaling in hepatic stellate cells
Hepatic fibrosis is the primary determinant of mortality in nonalcoholic steatohepatitis (NASH) patients. Antagonism of transforming growth factor (TGF), a master profibrogenic cytokine, is a promising therapeutic target that has not yet been translated into an effective therapy, due in part to the...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-05-06 | PXD035735 | Pride
Proteomics Nonalcoholic steatohepatitis Folate receptor gamma Transforming growth factor beta Hepatic stellate cells 
ProteomicsHIV-1 gp120 impairs spatial memory through CREB
HIV-associated neurocognitive disorders (HAND) remain an unsolved problem that persists despite using antiretroviral therapy. We have obtained data showing that HIV-gp120 protein contributes to neurodegeneration through metabolic reprogramming. This led to decreased ATP levels, lower mitochondrial D...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD031891 | Pride
Rolipram Mitochondria Creb protein Proteomics Hiv Neurodegeneration 
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