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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
TranscriptomicsMicroarray of neural progenitor cells from neonatal lung injury mice treated with placebo or umbilical-cord mesenchymal stromal cell extracellular vesicles or untreated, as well as age-matched control mice
The purpose of this experiment was to determine the transcriptional differences between neural progenitor cells from neonatal lung injury mice vs. control mice, as well as neonatal lung injury mice treated with umbilical-cord mesenchymal stromal cell extracellular vesicles vs. neonatal lung injury m...
ORGANISM(S): Mus musculus 
2022-05-17 | E-MTAB-11157 | biostudies-arrayexpress
TranscriptomicsRole of miRNAs in acute kidney injury recovery induced by mesenchymal stromal cells and derived extracellular vesicles.
Phenotypic changes induced by extracellular vesicles (EVs) have been implicated in the recovery of acute kidney injury (AKI) induced by mesenchymal stromal cells (MSCs). miRNAs are potential candidates for cell reprogramming towards a pro-regenerative phenotype. The aim of the present study was to e...
ORGANISM(S): Mus musculus 
2015-05-07 | E-GEOD-59958 | biostudies-arrayexpress
TranscriptomicsHuman iPSC-derived cardiomyocytes under hypoxia/normoxia, treated with bone marrow or cardiac stromal cell extracellular vesicles
RNA-seq was performed on cultured human induced pluripotent cell derived cardiomyocytes (iPSC-CMs). There are four groups, with three samples per group: H1,H2,H3. Negative control. Healthy, normoxic iPSC-CMs D1,D2,D3. Positive control. iPSCs cultured under hypoxic (0-1% O2) for 48h with 2% v/v PBS ...
ORGANISM(S): Homo sapiens 
2024-10-02 | E-MTAB-13966 | biostudies-arrayexpress
MetabolomicsCharacterization of small intracellular vesicles uncovers their potential as drug carriers and therapeutic agents

Small extracellular vesicles (sEVs) have been extensively investigated as a source of clinically relevant cargo. Alongside the secretion of EVs, such as exosomes, cells house a multitude of internal vesicles involved in various physiologic processes and metabolic activities. Herein, we developed ...

2025-09-02 | MTBLS12923 | MetaboLights
ProteomicsNeuroprotective properties of Mesenchymal Stromal Cell–Derived Extracellular Vesicles in Models of Acute Brain Pathology
Extracellular vesicles (EVs) of multipotent mesenchymal stromal cells (MSCs) in various studies have shown a wide range of cytoprotective effects, including neuroprotective ones. It is important to note that the therapeutic effect of EVs is observed regardless of the tissue from which MSCs were isol...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD027581 | Pride
Msc Extracellular vesicles Neuroprotection 
GenomicsSmall extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cell(MSC)s effectively treat liver fibrosis
Small extracellular vesicles derived from interferon-γ pre-conditioned mesenchymal stromal cell(MSC)s effectively treat liver fibrosis
PRJNA705354 | ENA
ProteomicsMesenchymal stem cell-derived extracellular vesicles
Therapeutic benefits of mesenchymal stem/stromal cells (MSCs) are now widely believed to come from their paracrine signalling, i.e. secreted factors such as cytokines, chemokines, and extracellular vesicles (EVs). Cell-free therapy using EVs is an active and emerging field in regenerative medicine. ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD029766 | Pride
Mesenchymal stem cell Culture Lung fibrosis Extracellular vesicles 
ProteomicsProteomic analysis of EVs from human UCMSC
Proteomic analysis of EVs from human Umbilical Cord Mesenchymal Stem Cells
ORGANISM(S): Homo Sapiens 
2024-09-02 | PXD055465 |
ProteomicsEnhanced Therapeutic Effects of Hypoxia-Preconditioned Mesenchymal Stromal Cell-Derived Extracellular Vesicles in Renal Ischemic Injury
Background Extracellular vesicles (EVs) secreted by mesenchymal stromal cells (MSCs) provide significant protection against renal ischemia-reperfusion injury (IRI). Hypoxia is considered an important method for enhancing the tissue repair capabilities of MSCs. However, the specific effects of hypoxi...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057088 | Pride
Hypoxia pretreated Anti-oxidative stress Extracellular vesicles Mesenchymal stromal cells Renal ischemia reperfusion injury 
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