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ProteomicsMET-G4_HepG2_Cell lysate_LC-MSMS
A biotin-labeled MET-G4-forming sequence was used as bait to capture proteins binding to MET-G4. In contrast, a biotin-labeled MET-G4-MUT sequence served as a control bait to exclude non-specific DNA-binding proteins. After incubation with cell lysate from HepG2 cells, the biotin-labeled sequences w...
ORGANISM(S): Homo sapiens (Human) 
2026-05-19 | PXD068846 | Pride
Met-g4 Hepg2 
GenomicsMolecule Glue That Stabilizes the LRPPRC-MET-G4 Interaction Complex to Drive MET Downregulation
Targeting the MET oncoprotein is an effective strategy in precision cancer therapy, whereas its clinical efficacy varies dramatically across tumor types. To address this challenge, we explored an alternative approach to downregulate MET expression at transcriptional levels. We identified a cis-regul...
ORGANISM(S): Homo sapiens 
2026-05-19 | GSE330177 | GEO
TranscriptomicsGlutamine Deprivation Triggers TRIB3-Dependent G4-DNA Resolution to Maintain DNA Repair and Tumor Survival [TRIB3]
Glutamine, the most abundant circulating amino acid, is a central metabolite critical for the survival and growth of many tumor cells. Efforts to exploit this vulnerability have met with limited success, due to the inherent adaptability of tumor cells to withstand nutrient scarcity in the tumor micr...
ORGANISM(S): Homo sapiens 
2026-03-13 | GSE307271 | GEO
TranscriptomicsGlutamine Deprivation Triggers TRIB3-Dependent G4-DNA Resolution to Maintain DNA Repair and Tumor Survival [Glutamin deprivation]
Glutamine, the most abundant circulating amino acid, is a central metabolite critical for the survival and growth of many tumor cells. Efforts to exploit this vulnerability have met with limited success, due to the inherent adaptability of tumor cells to withstand nutrient scarcity in the tumor micr...
ORGANISM(S): Homo sapiens 
2026-03-13 | GSE307270 | GEO
GenomicsGlutamine Deprivation Triggers TRIB3-Dependent G4-DNA Resolution to Maintain DNA Repair and Tumor Survival [CUT&Tag]
Glutamine, the most abundant circulating amino acid, is a central metabolite critical for the survival and growth of many tumor cells. Efforts to exploit this vulnerability have met with limited success, due to the inherent adaptability of tumor cells to withstand nutrient scarcity in the tumor micr...
ORGANISM(S): Homo sapiens 
2026-03-13 | GSE306768 | GEO
UnknownTherapeutic evaluation of monoclonal antibody-maytansinoid conjugate as a model of RON-targeted drug delivery for pancreatic cancer treatment.
Not available
S-EPMC4889711 | biostudies-literature
UnknownChronic kidney disease, physical activity and cognitive function in older adults-results from the National Health and Nutrition Examination Survey (2011-2014).
Not available
S-EPMC9585475 | biostudies-literature
UnknownImplications of BCRP modulation on PTZ-induced seizures in mice: Role of ko143 and metformin as adjuvants to lamotrigine.
Not available
S-EPMC10497685 | biostudies-literature
UnknownPharmaceutical quality of seven brands of diclofenac tablet on the Saudi market.
Not available
S-EPMC7694918 | biostudies-literature
UnknownComplete mitochondrial genome of Pseudoechthistatus hei (Coleoptera: Cerambycidae: Lamiinae) and its phylogenetic analysis.
Not available
S-EPMC9668276 | biostudies-literature
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