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MetabolomicsMetabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
The relationship between sequence variation and phenotype is poorly understood. Here, we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phenotype of E. coli strains that carry destabilizing mutations in dihydrofolate reductase (DHFR). We find that partial lo...
2021-06-30 | MTBLS2795 | MetaboLights
MetabolomicsClenbuterol exerts antidiabetic activity through metabolic reprogramming of skeletal muscle cells
Activation of the sympathetic nervous system causes pronounced metabolic changes that are mediated by multiple adrenergic receptor subtypes. Systemic treatment with β2-adrenergic receptor agonists results in multiple beneficial metabolic effects, including improved glucose homeostasis. To...
2022-08-26 | MTBLS467 | MetaboLights
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
MetabolomicsGinsenoside Rd2 improves allergic asthma by inhibiting PTGS2 enzyme activity
This study aims to elucidate the molecular mechanisms underlying the therapeutic effects of mountain-grown ginseng in allergic asthma and to systematically identify and characterize bioactive monomeric compounds responsible for these effects. We found that total saponins from mountain-grown ginseng ...
2026-04-13 | MTBLS14268 | MetaboLights
MetabolomicsImpact of reproductive activity on physiological metabolism and molecular regulation in the Genus scallopus(Mizuhopecten yessoensis)

Genus scallopus(Mizuhopecten yessoensis), a commercially important shellfish species in China, suffers a persistently high post-spawning mortality rate, severely constraining industry development. Thus, this study investigated the physiological and molecular impact of reproductive activity on M. ...

2025-06-28 | MTBLS12652 | MetaboLights
MetabolomicsVariety-Specific Polyphenol Accumulation and Antioxidant Activity Differences in Apple Fruits

Oxidative stress is a key inducer of chronic diseases, and apple polyphenols exhibit significant antioxidant potential. This study systematically analyzed polyphenol accumulation characteristics and antioxidant activity of four apple cultivars (Qincui, Jiuyue Qiji, Orin, Ruixue) using a multi-lev...

2026-01-14 | MTBLS13681 | MetaboLights
MetabolomicsGut microbiome structure and metabolic activity in inflammatory bowel disease
Not available
ORGANISM(S): Homo sapiens 
ST001000 | MetabolomicsWorkbench
MetabolomicsMetabolite control of enzyme activity links stress to biosynthetic regulation

Cells must continuously adjust metabolic output to maintain homeostasis under changing environmental conditions, yet the mechanisms that enable rapid and reversible control of pathway activity remain largely unknown. The methylerythritol phosphate (MEP) pathway, of bacterial origin and conserved ...

2026-02-04 | MTBLS12456 | MetaboLights
MetabolomicsData processing, multi-omic pathway mapping, and metabolite activity analysis using XCMS Online

Systems biology is the study of complex living organisms, and as such, analysis on a systems-wide scale involves the collection of information-dense data sets that are representative of an entire phenotype. To uncover dynamic biological mechanisms, bioinformatics tools have become essential to fa...

2017-11-23 | MTBLS572 | MetaboLights
MetabolomicsImmunomodulatory activity of hyaluronidase is associated with metabolic adaptations during acute inflammation
Not available
ORGANISM(S): Mus musculus 
ST001255 | MetabolomicsWorkbench
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