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TranscriptomicsThe effect of CuO nanoparticles on gene expression patterns in Daphnia magna
There is still a lot of contradiction on whether metal ions are solely responsible for the observed the toxicity of ZnO and CuO nanoparticles to aquatic species. While most tests have studied nanoparticle effects at organismal levels (e.g. mortality, reproduction), effects at suborganismal levels ma...
ORGANISM(S): Daphnia magna 
2014-03-01 | E-GEOD-54738 | biostudies-arrayexpress
TranscriptomicsThe effect of ZnO nanoparticles on gene expression patterns in Daphnia magna
There is still a lot of contradiction on whether metal ions are solely responsible for the observed the toxicity of ZnO and CuO nanoparticles to aquatic species. While most tests have studied nanoparticle effects at organismal levels (e.g. mortality, reproduction), effects at suborganismal levels ma...
ORGANISM(S): Daphnia magna 
2014-03-01 | E-GEOD-54736 | biostudies-arrayexpress
TranscriptomicsRNAseq of human epithelial lung carcinoma cell line A549 exposed to ceria, silver or zinc ions, micron-sized particles or nanoparticles
The toxicity of silver and zinc oxide nanoparticles is hypothesised to be mediated by dissolved metal ions and cerium dioxide nanoparticles (CeO2 NPs) are hypothesised to induce toxicity specifically by oxidative stress dependant on their surface redox state. To test these hypotheses, RNAseq was app...
ORGANISM(S): Homo sapiens 
2018-02-01 | E-MTAB-5734 | biostudies-arrayexpress
TranscriptomicsUnderstanding toxicity pathways of gold nanoparticles: RNA expression study on Caco-2 human colon carcinoma cells
A safer design and higher eficacy of nano-gold therapeutic formulations requires examination of cellular responses to gold nanoparticles (AuNPs). In this work we compared cellular uptake, cytotoxicity and RNA expression patterns induced in Caco-2 cells of citrate-stabilized Au NP of two different si...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-55349 | biostudies-arrayexpress
ProteomicsSelective organ deposition of nanoparticles directed by metal–organic network coatings_2
Despite significant advances in nanoengineering, developing a universal nanoparticle engineering strategy that enables tailored nanoparticle organ deposition post intravenous administration remains challenging. Here, we report a simple and modular strategy mediated by metal–organic network coatings ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-26 | PXD077631 | Pride
Nanoparticles  organ-targeted delivery  protein corona 
TranscriptomicsGene expression profile in zebrafish D. rerio exposed to metal oxidate nanoparticles
Metal oxide nanoparticles can exert adverse effects on humans and aquatic organisms. However, the toxic effects and mechanisms of MO-NPs are not clearly understood.We investigated the toxic effects and mechanisms of copper oxide, zinc oxide, and nickel oxide nanoparticles in Danio rerio using microa...
ORGANISM(S): Danio rerio 
2018-03-20 | GSE112016 | GEO
TranscriptomicsDNA methylation profiling of BEAS-2B cells exposed to low doses of Ag nanoparticles for 6 weeks
Human bronchial lung cells (BEAS-2B) were treated for 6 weeks with low doses (1 µg/mL) of Ag nanoparticles (10 nm citrate-coated). At the end of the exposure control and treated samples were submitted for DNA methylation analysis (Illumina 450k). The overall goal of this experiment was to evaluate p...
ORGANISM(S): Homo sapiens 
2018-04-30 | E-MTAB-6331 | biostudies-arrayexpress
ProteomicsFast and robust proteome screening platform identifies neutrophil extracellular trap formation in the lung in response to cobalt ferrite nanoparticles
The goal of this study was to investigate the effects of magnetic iron cobalt oxide nanoparticles (cobalt doped Fe3O4 nanoparticles with increasing amounts of cobalt) after pulmonary exposure while in parallel presenting a proteomics platform that is easily transferable to large-scale nanotoxicology...
ORGANISM(S): Mus musculus (Mouse) 
2020-03-26 | PXD016148 | Pride
Tmt Iron cobalt oxide nanoparticles Balf Lung Clinical proteomics Nanoparticles Mouse Murine Label-free Metal oxide nanoparticles Bronchoalveolar lavage fluid 
TranscriptomicsRNA-Seq of BEAS-2B cells treated with low doses of Ag nanoparticles for 6 weeks
Human bronchial lung cells (BEAS-2B) were treated for 6 weeks with low doses (1 µg/mL) of Ag nanoparticles (10 nm citrate coated). At the end of the exposure control and treated samples were submitted for RNA-Seq analysis (Hiseq2500). The overall goal of this experiment was to gain an in-depth under...
ORGANISM(S): Homo sapiens 
2018-04-30 | E-MTAB-6321 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of BEAS-2B cells treated with low doses of Ni and NiO nanoparticles as well as NiCl2 for 6 weeks
Human bronchial lung cells (BEAS-2B) were treated for 6 weeks with low doses (0.5 µg/mL) of Ni and NiO nanoparticles and NiCl2. At the end of the exposure control and treated samples were submitted for RNA-Seq analysis (Hiseq2500). The overall goal of this experiment was to gain an in-depth understa...
ORGANISM(S): Homo sapiens 
2020-04-19 | E-MTAB-8903 | biostudies-arrayexpress
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