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UnknownMetascape provides a biologist-oriented resource for the analysis of systems-level datasets.
Not available
S-EPMC6447622 | biostudies-literature
UnknownAfpdb: an efficient structure manipulation package for AI protein design.
Not available
S-EPMC11631506 | biostudies-literature
ProteomicsHK-2 cells 4D label quantitative lactylproteomic analysis
Following acute kidney injury (AKI), a substantial subset of patients experiences an irreversible progression to chronic kidney disease (CKD), yet the molecular determinants governing this maladaptive transition remain elusive, and effective clinical interventions are lacking. Here, we identify lact...
ORGANISM(S): Homo sapiens (Human) 
2026-07-18 | PXD078736 | Pride
Human  lactylation 
TranscriptomicsTranscriptome analysis of J558 allograft mouse model treated with the CDC7-specific inhibitor TAK-931 [RNA-seq]
To comprehensively evaluate in vivo inflammatory effects of TAK-931 in tumor microenvironment, RNA-seq was conducted in the J558 allograft mouse model. The GSEA revealed significant enrichment of inflammatory hallmarks in TAK-931-treated allografts. Metascape analyses also visualized that the networ...
ORGANISM(S): Mus musculus 
2023-11-05 | GSE244988 | GEO
ProteomicsTear Proteomics Analysis in Children and Adolescents with Type 1 Diabetes
Fifty-six children and adolescents with type 1 diabetes at least one year after diagnosis, aged 6-17 years old and fifty-six healthy age- and sex-matched subjects were enrolled in this cross-sectional study. Tear samples were collected using Schirmer strips placed on the lower eyelid. The proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD052994 | Pride
Diabetic complications Mass spectrometry Biomarkers Children Glycemic control Tear proteome Diabetic ketoacidosis Type 1 diabetes 
TranscriptomicsTranscriptome analysis of HeLa cells treated with the CDC7-specific inhibitor TAK-931 [RNA-seq]
The results showed that 48-h treatment upregulated 138 genes and 72-h treatment upregulated 504 genes. In the Metascape analyses, the TNF signaling pathway was a dominant network module in the 48-h treatment group, while the inflammatory-related modules were more intensively accumulated, and the sig...
ORGANISM(S): Homo sapiens 
2023-11-05 | GSE245063 | GEO
ProteomicsQuantitaQuantitative proteomic analysis of β-cells response to thapsigargin and rotenone uncovers key pathways of rat β-cell dysfunction tive proteomic analysis of β-cells response to thapsigargin and rotenone uncovers key pathways of rat β-cell dysfunction
We designed a TMT peptide labeling-based quantitative proteomics strategy to achieve a high-accuracy analysis of proteomic changes in response to ER stress and mitochondria stress on INS-1 cells under three different culture conditions: control (Cont), rotenone (Rot), and thapsigargin (Tpg), each wi...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-07-20 | PXD030711 | Pride
Endoplasmic reticulum (er) stress  mitochondria stress  quantitative proteomics  tmtpro  ins-1 beta cells Cells  metascape 
TranscriptomicsExpression and role of the receptor tyrosine kinase-like orphan receptor2 (ROR2) in small cell lung cancer
Heterogeneity of ROR2 was observed in the tumor tissues form patient-derived xenograft (PDX) model of SCLC, in which the cells with high ROR2 expression (ROR2high cell) and those without ROR2 expression (ROR2low cell) were gained and subjected to RNA sequence analysis. Cell proliferation activity wa...
ORGANISM(S): Homo sapiens 
2022-12-15 | GSE210388 | GEO
UnknownCausality between immune cells and HER2-breast cancer: A 2‑sample Mendelian randomization study.
Not available
S-EPMC12826194 | biostudies-literature
ProteomicsLncRNA EPR-induced METTL7A1 modulates target gene translation
EPR is a long non-coding RNA (lncRNA) that controls cell proliferation in mammary gland cells by regulating gene transcription. Here, we report on Mettl7a1 as a direct target of EPR. We show that EPR induces Mettl7a1 transcription by rewiring three-dimensional chromatin interactions at the Mettl7a1 ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD034398 | Pride
Lncerna Rna binding protein Translation 
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