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ProteomicsDiscovery of TBC1D7 as a potential driver for melanoma cell invasion.
Melanoma is a common type of cancer, and metastasis remains the leading cause for mortality in melanoma patients. In this study, we utilized an unbiased mass spectrometry-based quantitative proteomic method to assess, at the global proteome scale, differential protein expression in a matched pair of...
ORGANISM(S): Homo sapiens (Human) 
2022-08-15 | PXD014368 | Pride
Tbc1d7 Tbc domain-containing proteins Mass spectrometry Silac Melanoma metastasis Quantitative proteomics 
ProteomicsThe transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15R chain
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells also express a cleavable membrane-bound f...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD076097 | Pride
Il15 Cytokine Il15rα Skin cancer (melanoma) Natural killer (nk) cells 
ProteomicsG4 Quadruplex Binding Proteins
In this study we discover proteins that bind to G4 quadruplex DNA structure. We use modified c-myc quadruplex as a bait, and compare it to the control bait - T15 oligo. We use spectral counts and G-test to determine significant binders. T15 and G4 datafiles are uploaded
ORGANISM(S): Homo sapiens (Human) 
2016-07-07 | PXD003501 | Pride
Metastatic melanoma wm 266-4 cell lines 
Methylation profilingDNA methylation profile from three pairs of melanoma cell lines (WM115/W226-4 ; M4Be/M4BeS2 ; M4Be/TW12)
DNA methylation profile from three pairs of cell lines (WM115/W226-4 ; M4Be/M4BeS2 ; M4Be/TW12) with common genetic background (human) and derived in tree different organisms (human-rat-mouse) were analysed by Infinium Human Methylation 450 K bead arrays (Illumina Inc., San Diego, CA). The WM-115 ce...
ORGANISM(S): Homo sapiens 
2022-10-05 | GSE155856 | GEO
GenomicsDNA methylation profile from three pairs of melanoma cell lines (WM115/W226-4 M4Be/M4BeS2 M4Be/TW12)
DNA methylation profile from three pairs of melanoma cell lines (WM115/W226-4 M4Be/M4BeS2 M4Be/TW12)
PRJNA655840 | ENA
UnknownDiscovery of TBC1D7 as a Potential Driver for Melanoma Cell Invasion.
Not available
S-EPMC9362880 | biostudies-literature
UnknownQuantitative analysis of surface plasma membrane proteins of primary and metastatic melanoma cells.
Not available
S-EPMC4704867 | biostudies-literature
UnknownInvestigation of tryptophan to kynurenine degradation in response to interferon-γ in melanoma cell lines.
Not available
S-EPMC10770592 | biostudies-literature
GenomicsSNX18 inhibits melanoma migration by modulating the activation ratio of Cdc42 & RhoA
SNX18 inhibits melanoma migration by modulating the activation ratio of Cdc42 & RhoA
PRJNA491419 | ENA
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