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MetabolomicsMethod Comparison using DBS samples

Metabolomics serves as a critical pillar in clinical research, yet the lack of standardized protocols often limits the comparability of data across different platforms and institutions. The HUMAN (Harmonizing and Unifying Blood Metabolomics Network) has as one of its goals to to advance the field...

2026-05-19 | MTBLS14519 | MetaboLights
MetabolomicsDetermination and comparison of SCFAs in serum and colon content samples: Alzheimer's disease rat as a case study (Method validation)

SCFAs are the main microbial fermentation products from dietary fibers in colon and play a key role in keeping healthy in the whole-body. However, differences of SCFAs concentration in the serum and colon samples collected from rats had attracted few attentions. Here, we optimized the extract and...

2020-11-24 | MTBLS2146 | MetaboLights
MetabolomicsComparison of popular enrichment methods for untargeted in vitro metabolomics.

Introduction

Untargeted metabolomics is a popular method by which researchers measure a large portion of the metabolites present in a biological system at once. This approach usually results in complex data sets containing tens to hundreds of thousands of observations whi...

2025-08-11 | MTBLS12332 | MetaboLights
MetabolomicsMarine metabolomics: measurement of metabolites in seawater by gas chromatography mass spectrometry (Method development)
One of the major bottlenecks in describing marine ecosystems is characterizing the metabolome of seawater, as salt prevents metabolite analysis. We present SeaMet, a method that can detect hundreds of metabolites in less than one ml of seawater and quantifies them down to nano-molar levels using gas...
2019-11-15 | MTBLS826 | MetaboLights
MetabolomicsComparison of Two Different Astragali Radix by 1H NMR based Metabolomic Approach
Astragali Radix (AR) is a commonly used herbal drug in Traditional Chinese Medicine, and widely used for the treatment of diabetes, cardiovascular diseases, nephropathy and neuropathy. The main source of AR is the dried root of Astragalus membranaceus var. mongholicus (Bge.) Hsiao in China, and both...
2017-01-16 | MTBLS189 | MetaboLights
MetabolomicsAn LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma

Blood microsampling (BµS) devices collect less than 100 µL of blood, offering a less invasive and more cost-effective alternative to venipuncture. However, its metabolomic comparability to conventional samples remains unclear, and standardized BµS metabolomic workflows are lacking. This study com...

2026-06-01 | MTBLS10740 | MetaboLights
MetabolomicsA Cross-Platform Metabolomics Comparison Identifies Serum Metabolite Signatures of Liver Fibrosis Progression in Chronic Hepatitis C Patients
Metabolomics offers new insights into disease mechanisms that is enhanced when adopting orthogonal instrumental platforms to expand metabolome coverage, while also reducing false discoveries by independent replication. Herein, we report the first inter-method comparison when using multisegment injec...
2023-08-22 | MTBLS3111 | MetaboLights
MetabolomicsComparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial

Introduction

Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. D...
2022-02-21 | MTBLS2016 | MetaboLights
MetabolomicsComparison of Full-Scan, Data-Dependent, and Data-Independent Acquisition Modes in Liquid Chromatography-Mass Spectrometry Based Untargeted Metabolomics
Full-scan, data-dependent acquisition (DDA), and data-independent acquisition (DIA) are the three common data acquisition modes in high resolution mass spectrometry-based untargeted metabolomics. It is an important yet underrated research topic on which acquisition mode is more suitable for a given ...
2020-05-21 | MTBLS1572 | MetaboLights
MetabolomicsTranscriptomic and metabolomic comparison of two Kandelia obovata cultivas in response to cold wave
Temperature is the primary environmental factor that restricts the growth and distribution of mangrove plants. With the escalating severity of global climate change, Kandelia obovata has gained widespread recognition as an ideal species for investigating the response mechanisms of mangroves to cold ...
2024-09-27 | MTBLS9845 | MetaboLights
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