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TranscriptomicsPhenotypic and transcriptional profiling in Entamoeba histolytica reveal costs to fitness and adaptive responses associated with metronidazole resistance
In vitro studies have described metronidazole (MTZ) resistance and the potential mechanisms involved. Costs to fitness and adaptive responses associated with resistance, however, have not been investigated. In this study we generated an HM-1-derived strain resistant to 12 µM MTZ (MTZR). We examined ...
ORGANISM(S): Entamoeba histolytica 
2012-02-22 | E-GEOD-35990 | biostudies-arrayexpress
TranscriptomicsTranscriptional Metronidazole treatment
This study aims to search for the effect of 50uM Metronidazole against Entamoeba histolytica and thereby elucidating their mechanism of action
ORGANISM(S): Entamoeba histolytica 
2014-01-14 | E-MTAB-1763 | biostudies-arrayexpress
TranscriptomicsTranscriptional and functional analysis of trifluoromethionine resistance in Entamoeba histolytica
Previously, we have shown that in Entamoeba histolytica, methionine γ-lyase (EhMGL) downregulation results in trifluoromethionine resistance. The transcriptional response, however, of this parasite to the drug is not known. In this study, we used microarray analysis to determine if additional genes ...
ORGANISM(S): Entamoeba histolytica 
2011-11-16 | E-GEOD-32314 | biostudies-arrayexpress
ProteomicsFactors of metronidazole resistance in the human parasite Trichomonas vaginalis
Trichomonas vaginalis is a sexually transmitted human parasite causing trichomoniasis, leading to vaginitis or cervicitis in many patients. Furthermore, infections can lead to premature labour or loss of child as well as an increase in the risk of contracting HIV. For treatment the antibiotic 5-nitr...
ORGANISM(S): Trichomonas vaginalis 
2025-03-10 | PXD051345 | Pride
Trichomonas vaginalis Metronidazole resistance Parasite Sexually transmitted disease Antibiotic resistance Comparative proteomic analysis Lc-ms/ms 
ProteomicsProteomic analysis of metronidazole resistance in the human facultative pathogen Bacteroides fragilis
Bacteroides fragilis is an anaerobic commensal in the human gut which can act as opportunistic pathogen when leaving its intestinal niche to reach other body sites. Bacteroides infections have a high lethality and must be treated by antimicrobial chemotherapy. Metronidazole is one of the most freque...
ORGANISM(S): Bacteroides fragilis (strain 638R) 
2023-03-20 | PXD039809 | Pride
Shotgun proteomics Bacteroides fragilis Metronidayole resistance 
ProteomicsComparative LC-MS analysis of two metronidazole resistant (M1,M2) and one revertant (M1NR) Giardia intestinalis strains with their parental strain (WB-C6)
I this study we analyzed three lines, two of which were created by UV- directed mutagenesis and showed increased levels of metronidazole tolerance (M1 and M2) and the third being a line that reverted spontanously to sensitive after several passages (M1NR) of M1 without metronidazole in the media. On...
ORGANISM(S): Giardia lamblia ATCC 50803 
2022-01-26 | PXD027813 | Pride
Metronidazole resistance Giardia intestinalis Lc-ms 
ProteomicsProteomic signatures of metronidazole-resistant Trichomonas vaginalis
We conducted iTRAQ-based analysis to profile the proteomes of metronidazole-sensitive (MTZ-S) and MTZ-resistant (MTZ-R) parasites.
ORGANISM(S): Trichomonas vaginalis 
2021-09-09 | PXD018522 | Pride
Trichomonas vaginalis Metronidazole resistance Proteome 
GenomicsMetronidazole resistance in Clostridioides difficile.
Emergence of high-level and stable metronidazole resistance in Clostridioides difficile.
PRJEB37089 | ENA
GenomicsMetronidazole resistance in Clostridioides difficile is conferred by a plasmid
Metronidazole resistance in Clostridioides difficile is conferred by a plasmid
PRJEB24167 | ENA
MetabolomicsEnhanced fatty acid synthesis by Sigma28 in stringent responses contributes to multidrug resistance and biofilm formation in Helicobacter pylori

The metabolism of bacteria is closely associated with antibiotic resistance, yet the role of metabolism in the resistance of Helicobacter pylori remains unclear. In this study, we conducted integrated analysis using transcriptomics and non-targeted metabolomics to investigate the metabolic change...

2024-06-26 | MTBLS9981 | MetaboLights
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