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ProteomicsCharacterization of the biochemical activity and tumor-promoting role of the dual protein methyltransferase METL-13/METTL13 in Caenorhabditis elegans
The methyltransferase-like protein 13 (METTL13) methylates the eukaryotic elongation factor 1 alpha (eEF1A) on two locations: the N-terminal amino group and lysine 55. The absence of this methylation leads to reduced protein synthesis and cell proliferation in human cancer cells. Previous studies sh...
ORGANISM(S): Caenorhabditis elegans 
2023-07-03 | PXD042540 | Pride
Mettl13 Methylation C. elegans Eef1a Protein synthesis 
ProteomicsNascent proteomic profiling of a METTL13-dependent oncogenic translational program
We previously identified an orphan protein METTL13 (methyltransferase-like protein13) as the physiologic enzyme that specifically catalyzes dimethylation of eEF1A at lysine 55 (eEF1AK55me2). Targeting of METTL13 may have potent anti-cancer activity while causing minimal toxicity in normal tissues. T...
ORGANISM(S): Homo sapiens (Human) 
2026-08-15 | PXD062091 | Pride
Silac  mettl13  eef1ak55 dimethylation  newly synthesized protein  cancer 
UnknownMETTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Not available
S-EPMC6499081 | biostudies-literature
UnknownModifier variant of METTL13 suppresses human GAB1-associated profound deafness.
Not available
S-EPMC5873844 | biostudies-literature
UnknownMETTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion.
Not available
S-EPMC4725887 | biostudies-literature
UnknownStructure, Activity and Function of the Dual Protein Lysine and Protein N-Terminal Methyltransferase METTL13.
Not available
S-EPMC8624817 | biostudies-literature
UnknownMETTL13 facilitates cell growth and metastasis in gastric cancer via an eEF1A/HN1L positive feedback circuit.
Not available
S-EPMC10030728 | biostudies-literature
GenomicsThe dual methyltransferase METTL13 targets N-terminus and Lys55 of eEF1A and regulates codon-specific translation rates
The dual methyltransferase METTL13 targets N-terminus and Lys55 of eEF1A and regulates codon-specific translation rates
PRJNA408071 | ENA
UnknownOpposing regulation of the Nα-trimethylase METTL11A by its family members METTL11B and METTL13.
Not available
S-EPMC10166787 | biostudies-literature
TranscriptomicsThe dual methyltransferase METTL13 targets N-terminus and Lys55 of eEF1A and regulates codon-specific translation rates
Eukaryotic elongation factor 1 alpha (eEF1A) delivers aminoacyl-tRNA to the ribosome and thereby plays a key role in protein synthesis. Human eEF1A is post-translationally methylated on several lysine residues as well as on the N-terminus and until recently the responsible methyltransferases were la...
ORGANISM(S): Homo sapiens 
2018-07-04 | GSE104033 | GEO
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