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TranscriptomicssVEGFR-1 signaling through α5β1 integrin
Soluble VEGFR-1 (sVEGFR-1) acts both as a decoy receptor for VEGFs and as an extracellular matrix protein for α5β1 integrin. A sVEGFR-1-derived peptide that interacts with α5β1 integrin promotes angiogenesis. However, canonical signal downstream integrin activation is not induced, resulting into...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-GEOD-32560 | biostudies-arrayexpress
ProteomicsOptineurin links Hace1-dependent Rac ubiquitylation 1 to integrin-mediated mechanotransduction to control bacterial invasion and cell divisionOptineurin links Hace1-dependent Rac ubiquitylation 1 to integrin-mediated mechanotransduction to control bacterial invasion and cell division
Extracellular matrix (ECM) elasticity is perceived by cells via focal adhesion structures, which transduce mechanical cues into chemical signaling to conform cell behavior. Although the contribution of ECM compliance to the control of cell migration or division has been extensively studied, little h...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD035396 | Pride
Mechanotransduction Host-pathogen interaction Cnf1 toxin E3 ubiquitin ligase Rac1 gtpase Tumor suppressor Integrin signaling 
UnknownGroup-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination.
Not available
S-EPMC5780496 | biostudies-literature
ProteomicsA survival mechanism controlled by cadherins and Dlg1 polarity complex inhibits Fas cell death receptor signaling
A fine regulation of epithelia cell death is required to maintain tissue integrity and homeostasis. At a cellular level, this life and death decision is controlled by environmental stimuli including death receptors activation. Here, we show that establishment of cell polarity and AJ formation contro...
ORGANISM(S): Homo sapiens (Human) 
2018-09-20 | PXD009659 | Pride
Human Lc-msms Cell polarity Pdz Epithelia Death receptor Cell death 
UnknownCNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.
Not available
S-EPMC6693396 | biostudies-literature
UnknownInactivation of AtRac1 by abscisic acid is essential for stomatal closure.
Not available
S-EPMC312738 | biostudies-literature
TranscriptomicsTranscription profiling of human cells treated with Bacillus anthracis lethal toxin (LT)-intoxicated HUVECs monolayers
We have analyzed the variation of transcriptome of HUVECs intoxicated by the lethal toxin of Bacillus anthracis at 4 and 8 hours Experiment Overall Design: Three experimental conditions with two biological replicates for the control condition corresponding to untreated HUVEC monolayer. RNA were extr...
ORGANISM(S): Homo sapiens 
2010-01-29 | E-GEOD-12131 | biostudies-arrayexpress
UnknownActo-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity.
Not available
S-EPMC6318293 | biostudies-literature
UnknownUBTD1 is a mechano-regulator controlling cancer aggressiveness.
Not available
S-EPMC6446246 | biostudies-literature
UnknownUBTD1 is a mechano-regulator controlling cancer aggressiveness
Not available
S-SCDT-EMBOR-2018-46570V1 | biostudies-other
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