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TranscriptomicsThe insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome: DamID
Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in ...
ORGANISM(S): Drosophila melanogaster 
2011-01-24 | E-GEOD-20311 | biostudies-arrayexpress
TranscriptomicsThe insulator protein SU(HW) modulates nuclear lamina interactions of the Drosophila genome: expression
Specific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in ...
ORGANISM(S): Drosophila melanogaster 
2011-01-24 | E-GEOD-20312 | biostudies-arrayexpress
TranscriptomicsEvolutionary conservation of nuclear lamina-genome interactions
Regulation of gene expression is highly conserved between vertebrates, yet the genomic binding patterns of transcription factors are poorly conserved, suggesting that other mechanisms may contribute. The spatial organization of chromosomes in the nucleus is known to affect gene activity, but it is u...
ORGANISM(S): Homo sapiens 
2012-10-10 | E-GEOD-22428 | biostudies-arrayexpress
TranscriptomicsReorganization of nuclear lamina – genome interactions upon differentiation of embryonic stem cells.
The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. We present a genome-wide analysis of the interactions between chromatin and the nuclear lamina during differentiation of mouse embryonic stem cells (ESCs) into lineage-co...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-17051 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (RNA-Seq)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-48607 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (mPGK TRIP pools)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-48608 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (cell lines with mPGK IRs)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-49807 | biostudies-arrayexpress
TranscriptomicsChromatin position effects assayed by thousands of reporters integrated in parallel (tet-Off TRIP pools)
Reporter genes integrated into the genome are a powerful tool to reveal effects of regulatory elements and local chromatin context on gene expression. However, so far such reporter assays have been of low throughput. Here we describe a multiplexing approach for the parallel monitoring of transcripti...
ORGANISM(S): Mus musculus 
2013-08-16 | E-GEOD-49806 | biostudies-arrayexpress
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