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ProteomicsoptiPRM: A targeted immunopeptidomics LC-MS workflow with ultra-high sensitivity for the detection of mutation-derived tumor neoepitopes from limited input material
Personalized cancer immunotherapies such as vaccines and T cell receptor (TCR)-transgenic T cells rely on the presentation of tumor-specific peptides by human leukocyte antigen (HLA) class I molecules to cytotoxic T cells. Such neoepitopes can for example arise from somatic mutations and their ident...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD043542 | Pride
Immunopeptidomics Prm Lc-ms Targeted ms 
TranscriptomicsRNA-seq from tibialis muscles from rats aged 15 months (adult) and 27 months (old)
To gain new insights into molecular changes in skeletal muscle aging and disease with a special focus on differential alternative splicing and senescence, we performed RNA-seq on tibialis muscles from 15 months old (adult, a) and 27 months old (old, o) rats. Whole (w) muscle samples were prepared fo...
ORGANISM(S): Rattus norvegicus 
2021-06-26 | E-MTAB-10582 | biostudies-arrayexpress
TranscriptomicsRNA-seq from gastrocnemius muscles from rats aged 6, 12, 18, 21, 24 and 27 months
To gain new insights into molecular changes in skeletal muscle aging and disease with a special focus on differential alternative splicing and senescence, we performed RNA-seq on rat gastrocnemius muscles of animals aged 6, 12, 18, 21, 24 and 27 months, using a rat sarcopenia model we had previously...
ORGANISM(S): Rattus norvegicus 
2021-06-26 | E-MTAB-10583 | biostudies-arrayexpress
TranscriptomicsTranscriptome and proteome analysis of tyrosine kinase treated canine mast cell tumour cells identifies potentially KIT signalling-dependent genes
Canine mast cell tumour proliferation depends to a large extent on the activity of KIT, a tyrosine kinase receptor. Inhibitors of the KIT tyrosine kinase have recently been introduced and successfully applied as a therapeutic agent for this tumour type. However, little is known on the downstream tar...
ORGANISM(S): Canis lupus familiaris 
2012-07-24 | E-GEOD-32657 | biostudies-arrayexpress
ProteomicsTherapeutic targeting of ATR in alveolar rhabdomyosarcoma
Despite advances in multi-modal treatment approaches, clinical outcomes of patients suffering from PAX3-FOXO1 fusion oncogene-expressing alveolar rhabdomyosarcoma (ARMS) remain dismal. Here we show that PAX3-FOXO1-expressing ARMS cells are sensitive to pharmacological ataxia telangiectasia and Rad3 ...
ORGANISM(S): Homo Sapiens (human) 
2022-07-11 | PXD035131 | JPOST Repository
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